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Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition
Zhu,Pan1; Zhang,Yuan Ming1; Yin,Xuan2; Zhang,Xiao Hong1; Wang,Feng3; Zhang,Jin Jie4; Yan,Wang5; Xi,Yang1; Wan,Jian Bo6; Kang,Jing Xuan7; Zou,Zu Quan1; Bu,Shi Zhong1
2016-12-01
Source PublicationJournal of Functional Foods
ISSN1756-4646
Volume27Pages:483-490
AbstractMalignant melanoma is an aggressive cancer of neuroectodermal origin. The mechanisms of n-3 polyunsaturated fatty acids (PUFAs) against melanoma metastasis are not clear. Here fat-1 and wild type (WT) mice were injected with B16F10 melanoma cells via the tail vein to establish lung metastasis model. Endogenous n-3 PUFAs were associated with a reduction in grossly visible pulmonary metastases and outgrowth through inhibition of mesenchymal to epithelial transition (MET), which was characterized by decreased expression of epithelial markers E-cadherin and ZO-1, and increased expression of mesenchymal marker vimentin in tumour tissues from fat-1 mice compared with WT controls. In addition, n-3 PUFA-mediated inhibition of MET may have been associated, in part, with the: (i) formation of n-3 PUFA-derived lipid mediators and (ii) decreased expression of mature IL-1β and p-NF-κB, and enhanced expression of superoxide dismutase-1. These results suggest that n-3 PUFAs exert their antitumourigenic activities, in part, via their anti-inflammatory properties.
KeywordFat-1 IL-1β Lipid mediators Melanoma Mesenchymal to epithelial transition n-3 polyunsaturated fatty acids
DOI10.1016/j.jff.2016.10.006
URLView the original
Language英語English
Scopus ID2-s2.0-84993982886
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Medical School,Ningbo University,Ningbo,315211,China
2.Nutrition Department,First People's Hospital of Hangzhou,Hangzhou,310006,China
3.Clinical Laboratory,Lihuili Hospital,Ningbo,315040,China
4.Maritime Faculty,Ningbo University,Ningbo,315211,China
5.Neurosurgery Department,Second Hospital of Ningbo,Ningbo,315010,China
6.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,519000,Macao
7.Laboratory for Lipid Medicine and Technology,Massachusetts General Hospital and Harvard Medical School,Boston,02114,United States
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Zhu,Pan,Zhang,Yuan Ming,Yin,Xuan,et al. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition[J]. Journal of Functional Foods,2016,27:483-490.
APA Zhu,Pan,Zhang,Yuan Ming,Yin,Xuan,Zhang,Xiao Hong,Wang,Feng,Zhang,Jin Jie,Yan,Wang,Xi,Yang,Wan,Jian Bo,Kang,Jing Xuan,Zou,Zu Quan,&Bu,Shi Zhong.(2016).Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition.Journal of Functional Foods,27,483-490.
MLA Zhu,Pan,et al."Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition".Journal of Functional Foods 27(2016):483-490.
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