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Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy
Han,Congwei1; Song,Jinji1; Hu,Junqing1; Fu,Huijie1; Feng,Yanxian2; Mu,Ruoyu2; Xing,Zhen1; Wang,Zhenzhen2,4; Wang,Lintao1,2; Zhang,Junfeng1,4; Wang,Chunming2; Dong,Lei1,3
Source PublicationCell Reports

Administration of probiotics to regulate the immune system is a potential anti-tumor strategy. However, oral administration of probiotics is ineffective because of the poor inhabitation of exogenous bacteria in host intestines. Here we report that smectite, a type of mineral clay and established anti-diarrhea drug, promotes expansion of probiotics (especially Lactobacillus) in the murine gut and subsequently elicits anti-tumor immune responses. The ion-exchangeable microstructure of smectite preferentially promotes lactic acid bacteria (LABs) to form biofilms on smectite in vitro and in vivo. In mouse models, smectite laden with LAB biofilms (Lactobacillus and Bifidobacterium) inhibits tumor growth (when used alone) and enhances the efficacy of chemotherapy or immunotherapy (when used in combination with either of them) by activating dendritic cells (DCs) via Toll-like receptor 2 (TLR2) signaling. Our findings suggest oral administration of smectite as a promising strategy to enrich probiotics in vivo for cancer immunotherapy. Han et al. reveal that smectite, a mineral clay and established anti-diarrhea drug, has anti-cancer efficacy in mice by promoting expansion of probiotics in the gut that, in turn, activate dendritic cells via Toll-like receptor 2 signaling.

KeywordBiofilm Cancer Therapy Gut Microbiome Probiotics Smectite
URLView the original
Indexed BySCIE
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000617458200002
Scopus ID2-s2.0-85100481337
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang,Junfeng; Wang,Chunming; Dong,Lei
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,210023,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,
3.Chemistry and Biomedicine Innovation Center,Nanjing University,Nanjing,210023,China
4.Medical School of Nanjing University,Nanjing,21093,China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Han,Congwei,Song,Jinji,Hu,Junqing,et al. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy[J]. Cell Reports,2021,34(6).
APA Han,Congwei,Song,Jinji,Hu,Junqing,Fu,Huijie,Feng,Yanxian,Mu,Ruoyu,Xing,Zhen,Wang,Zhenzhen,Wang,Lintao,Zhang,Junfeng,Wang,Chunming,&Dong,Lei.(2021).Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy.Cell Reports,34(6).
MLA Han,Congwei,et al."Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy".Cell Reports 34.6(2021).
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