UM  > Institute of Chinese Medical Sciences
Affiliated with RCfalse
Status已發表Published
Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy
Han,Congwei1; Song,Jinji1; Hu,Junqing1; Fu,Huijie1; Feng,Yanxian2; Mu,Ruoyu2; Xing,Zhen1; Wang,Zhenzhen2,4; Wang,Lintao1,2; Zhang,Junfeng1,4; Wang,Chunming2; Dong,Lei1,3
2021-02-09
Source PublicationCell Reports
ISSN2211-1247
Volume34Issue:6
Abstract

Administration of probiotics to regulate the immune system is a potential anti-tumor strategy. However, oral administration of probiotics is ineffective because of the poor inhabitation of exogenous bacteria in host intestines. Here we report that smectite, a type of mineral clay and established anti-diarrhea drug, promotes expansion of probiotics (especially Lactobacillus) in the murine gut and subsequently elicits anti-tumor immune responses. The ion-exchangeable microstructure of smectite preferentially promotes lactic acid bacteria (LABs) to form biofilms on smectite in vitro and in vivo. In mouse models, smectite laden with LAB biofilms (Lactobacillus and Bifidobacterium) inhibits tumor growth (when used alone) and enhances the efficacy of chemotherapy or immunotherapy (when used in combination with either of them) by activating dendritic cells (DCs) via Toll-like receptor 2 (TLR2) signaling. Our findings suggest oral administration of smectite as a promising strategy to enrich probiotics in vivo for cancer immunotherapy. Han et al. reveal that smectite, a mineral clay and established anti-diarrhea drug, has anti-cancer efficacy in mice by promoting expansion of probiotics in the gut that, in turn, activate dendritic cells via Toll-like receptor 2 signaling.

KeywordBiofilm Cancer Therapy Gut Microbiome Probiotics Smectite
DOI10.1016/j.celrep.2021.108706
URLView the original
Indexed BySCIE
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000617458200002
Scopus ID2-s2.0-85100481337
Fulltext Access
Citation statistics
Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang,Junfeng; Wang,Chunming; Dong,Lei
Affiliation1.State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing,210023,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,
3.Chemistry and Biomedicine Innovation Center,Nanjing University,Nanjing,210023,China
4.Medical School of Nanjing University,Nanjing,21093,China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Han,Congwei,Song,Jinji,Hu,Junqing,et al. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy[J]. Cell Reports,2021,34(6).
APA Han,Congwei,Song,Jinji,Hu,Junqing,Fu,Huijie,Feng,Yanxian,Mu,Ruoyu,Xing,Zhen,Wang,Zhenzhen,Wang,Lintao,Zhang,Junfeng,Wang,Chunming,&Dong,Lei.(2021).Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy.Cell Reports,34(6).
MLA Han,Congwei,et al."Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy".Cell Reports 34.6(2021).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Han,Congwei]'s Articles
[Song,Jinji]'s Articles
[Hu,Junqing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Han,Congwei]'s Articles
[Song,Jinji]'s Articles
[Hu,Junqing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Han,Congwei]'s Articles
[Song,Jinji]'s Articles
[Hu,Junqing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.