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Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2
Hu,Le' an1,3; Zhang,Yao1; Zhang,Qing Wen3; Yin,Qin1,2; Zhang,Xumu1
2020-01-17
Source PublicationAngewandte Chemie - International Edition
ISSN1433-7851
Volume59Issue:13Pages:5321-5325
Abstract

A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.

KeywordAmines Diaryl Ketones Homogeneous Catalysis Reductive Amination Ruthenium
DOI10.1002/anie.201915459
URLView the original
Indexed BySCIE ; IC ; CCR-E
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000514492100001
Scopus ID2-s2.0-85079809190
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYin,Qin
Affiliation1.Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
2.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518055,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Hu,Le' an,Zhang,Yao,Zhang,Qing Wen,et al. Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2[J]. Angewandte Chemie - International Edition,2020,59(13):5321-5325.
APA Hu,Le' an,Zhang,Yao,Zhang,Qing Wen,Yin,Qin,&Zhang,Xumu.(2020).Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2.Angewandte Chemie - International Edition,59(13),5321-5325.
MLA Hu,Le' an,et al."Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2".Angewandte Chemie - International Edition 59.13(2020):5321-5325.
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