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CuH-Catalyzed Atropoenantioselective Reduction of Bringmann's Lactones via Dynamic Kinetic Resolution
Hu,Le'An1,2; Zhang,Yao3; Chen,Gen Qiang2,3; Lin,Bi Jin2; Zhang,Qing Wen1; Yin,Qin3; Zhang,Xumu2,4
2019-06-27
Source PublicationOrganic Letters
ISSN1523-7060
Volume21Issue:14Pages:5575-5580
Abstract

A CuH-catalyzed atropoenantioselective reduction of Bringmann's lactones via dynamic kinetic resolution has been disclosed. This protocol features a broad substrate scope and good functional group tolerance and allows the rapid assembly of various valuable axially chiral biaryls in good to high yields (up to 92% yield) with high to excellent enantioselectivities (up to 96% ee). Moreover, this report represents a rare example that a carbonyl group of esters is reduced under homogeneous asymmetric CuH catalysis.

DOI10.1021/acs.orglett.9b01907
URLView the original
Indexed BySCIE ; IC ; CCR-E
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000476957200043
Scopus ID2-s2.0-85068333652
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang,Qing Wen; Yin,Qin; Zhang,Xumu
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
3.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518000,China
4.Shenzhen Grubbs Institute,Shenzhen,518055,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Hu,Le'An,Zhang,Yao,Chen,Gen Qiang,et al. CuH-Catalyzed Atropoenantioselective Reduction of Bringmann's Lactones via Dynamic Kinetic Resolution[J]. Organic Letters,2019,21(14):5575-5580.
APA Hu,Le'An,Zhang,Yao,Chen,Gen Qiang,Lin,Bi Jin,Zhang,Qing Wen,Yin,Qin,&Zhang,Xumu.(2019).CuH-Catalyzed Atropoenantioselective Reduction of Bringmann's Lactones via Dynamic Kinetic Resolution.Organic Letters,21(14),5575-5580.
MLA Hu,Le'An,et al."CuH-Catalyzed Atropoenantioselective Reduction of Bringmann's Lactones via Dynamic Kinetic Resolution".Organic Letters 21.14(2019):5575-5580.
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