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Neuroprotective effects of quercetin in alzheimer’s disease
Khan,Haroon1; Ullah,Hammad1; Aschner,Michael2; Cheang,Wai San3; Akkol,Esra Küpeli4
2020
Source PublicationBiomolecules
Volume10Issue:1
Abstract

Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

KeywordAlzheimer’s Disease Clinical Directions Mechanistic Insights Polyphenols Quercetin
DOI10.3390/biom10010059
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000514863200125
Scopus ID2-s2.0-85077564487
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Cited Times [WOS]:44   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKhan,Haroon
Affiliation1.Department of Pharmacy,Abdul Wali Khan University,Mardan,23200,Pakistan
2.Department of Molecular Pharmacology,Albert Einstein College of Medicine,Bronx,Forchheimer 209, 1300 Morris Park Avenue,10461,United States
3.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macau,China
4.Department of Pharmacognosy,Faculty of Pharmacy,Gazi University,Ankara,Etiler,06330,Turkey
Recommended Citation
GB/T 7714
Khan,Haroon,Ullah,Hammad,Aschner,Michael,et al. Neuroprotective effects of quercetin in alzheimer’s disease[J]. Biomolecules,2020,10(1).
APA Khan,Haroon,Ullah,Hammad,Aschner,Michael,Cheang,Wai San,&Akkol,Esra Küpeli.(2020).Neuroprotective effects of quercetin in alzheimer’s disease.Biomolecules,10(1).
MLA Khan,Haroon,et al."Neuroprotective effects of quercetin in alzheimer’s disease".Biomolecules 10.1(2020).
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