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Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease
Xiong, Sha1; Li, Zhongjun2; Liu, Yao1; Wang, Qun1; Luo, Jingshan1; Chen, Xiaojia3; Xie, Zhongjian2; Zhang, Yuan4; Zhang, Han2; Chen, Tongkai1
2020-11-01
Source PublicationBiomaterials
ISSN0142-9612
Volume260Pages:120339
Abstract

The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.

KeywordBlack Phosphorus Nanosheets Blood-brain Barrier Brain Targeting Drug Delivery Lactoferrin
DOI10.1016/j.biomaterials.2020.120339
URLView the original
Indexed BySCIE
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
WOS IDWOS:000629742800004
Scopus ID2-s2.0-85089805651
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Cited Times [WOS]:40   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang, Han; Chen, Tongkai
Affiliation1.Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou,510405,China
2.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Institute of Microscale Optoelectronics,And Otolaryngology Department and Biobank of the First Affiliated Hospital,Shenzhen Second People's Hospital,Health Science Center,Shenzhen University,Shenzhen,518060,China
3.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,999078,Macao
4.Department of Neurosurgery,Shenzhen Key Laboratory of Neurosurgery,The First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital,Shenzhen University,Shenzhen,518035,China
Recommended Citation
GB/T 7714
Xiong, Sha,Li, Zhongjun,Liu, Yao,et al. Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease[J]. Biomaterials,2020,260:120339.
APA Xiong, Sha,Li, Zhongjun,Liu, Yao,Wang, Qun,Luo, Jingshan,Chen, Xiaojia,Xie, Zhongjian,Zhang, Yuan,Zhang, Han,&Chen, Tongkai.(2020).Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease.Biomaterials,260,120339.
MLA Xiong, Sha,et al."Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease".Biomaterials 260(2020):120339.
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