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Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy
Luo,Kaipei1; Yin,Shaoping1; Zhang,Ruixia1; Yu,Hua2; Wang,Guangji3; Li,Juan1
2020-11-15
Source PublicationInternational Journal of Pharmaceutics
ISSN0378-5173
Volume589
Abstract

The efficient delivery of chemotherapeutic drugs to the tumor tissues unavoidably encounters numerous obstacles, such as poor tumor targeting capability, slow intracellular drug release and massive accumulation in the liver. In this study, by self-assembling methoxy poly (ethylene glycol)-poly (lactide) block copolymer (mPEG-PLA) and hyaluronic acid-paclitaxel conjugate (HA-PTX), the composite nanoparticles (mPPHP NPs) were fabricated for efficient therapy of cancer. mPPHP NPs formed self-assembled nanoparticles (116 nm in diameter) with a narrow size distribution; and showed a rapid release of PTX in the presence of hyaluronidase and esterase. mPPHP NPs exhibited enhanced internalization by cells via CD44 receptors and selected cytotoxicity against A549 cells in vitro. More importantly, compared with other PTX formulations, mPPHP NPs were demonstrated to present the reduced liver accumulation, excellent tumor-targeting ability and superior antitumor efficacy in vivo, with a TIR of 75.9%. The multifunctional composite nanoparticles could be developed as a promising nano-carrier for improved therapeutic efficacy.

KeywordEnhanced Anticancer Efficacy Enzyme-sensitive Hyaluronic Acid Polymeric Conjugates Tumor Targeting
DOI10.1016/j.ijpharm.2020.119870
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000580654300067
Scopus ID2-s2.0-85090706025
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLi,Juan
Affiliation1.State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical University,Nanjing,210009,China
2.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macao SAR,China
3.Center of Pharmacokinetics,Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing,210009,China
Recommended Citation
GB/T 7714
Luo,Kaipei,Yin,Shaoping,Zhang,Ruixia,et al. Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy[J]. International Journal of Pharmaceutics,2020,589.
APA Luo,Kaipei,Yin,Shaoping,Zhang,Ruixia,Yu,Hua,Wang,Guangji,&Li,Juan.(2020).Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy.International Journal of Pharmaceutics,589.
MLA Luo,Kaipei,et al."Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy".International Journal of Pharmaceutics 589(2020).
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