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Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways
Li,Qiuping1; Wang,Guifang2; Xiong,Shi Hang3; Cao,Yuxue1,4; Liu,Baojun1,4; Sun,Jing1,4; Li,Lulu1,4; Mohammadtursun,Nabijan1,4; Yu,Hua3; Dong,Jingcheng1,4; Wu,Jinfeng1,5
2020-10-28
Source PublicationJournal of Ethnopharmacology
ISSN0378-8741
Volume261
Abstract

Ethnopharmacological relevance: Chronic obstructive pulmonary disease (COPD) is a respiratory inflammatory disease. Unlike asthma, COPD is insensitive to glucocorticoid treatment; thus, it is of great importance to find alternative medications, including Chinese medicine, to suppress inflammation. Bu-Shen-Fang-Chuan formula (BSFCF) is commonly used for the treatment of COPD in China. However, the mechanisms of BSFCF in COPD treatment are still unclear. Aim of the study: To verify the anti-inflammatory efficacy of BSFCF in COPD and to explore the possible mechanisms underlying its anti-inflammatory efficacy based on the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)-Nuclear factor erythroid 2-related factor 2 (Nrf2) and Nuclear factor (NF)-κB signalling pathways. Materials and methods: A rat model of COPD was established by chronic exposure to cigarette smoke (CS) for 6 months. Bronchoalveolar lavage fluid (BALF) and blood were obtained to detect inflammatory cytokines. Lung samples were harvested, and part of each sample was fixed for subsequent H&E staining and immunohistochemical (IHC) analysis. The remaining lung tissues were used for RNA sequencing analysis and western blotting. Results: BSFCF significantly reduced inflammatory infiltration in the lungs of CS-exposed rats and decreased the concentrations of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in both the BALF and serum. Additionally, BSFCF evidently attenuated NF-κB activation and downregulation of glucocorticoid receptor (GR) caused by CS. Furthermore, BSFCF increased the activation of PI3K/Akt-Nrf2 signalling in response to CS. Conclusions: BSFCF attenuated CS-induced inflammation in COPD, which was partially achieved through the PI3K/Akt-Nrf2 and NF-κB signalling pathways.

KeywordBu-shen-fang-chuan Formula (Bsfcf) Copd Inflammation Nrf2 Pi3k/akt
DOI10.1016/j.jep.2020.113095
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000566339500006
Scopus ID2-s2.0-85087369179
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong,Jingcheng; Wu,Jinfeng
Affiliation1.Department of Integrative Medicine,Huashan Hospital,Fudan University,Shanghai,12 Middle Urumqi Road,200040,China
2.Department of Respiratory Diseases,Huashan Hospital,Fudan University,Shanghai,12 Middle Urumqi Road,200040,China
3.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macao,Macao
4.Institutes of Integrative Medicine,Fudan University,Shanghai,12 Middle Urumqi Road,200040,China
5.Department of Dermatology,Huashan Hospital,Fudan University,Shanghai,12 Middle Urumqi Road,200040,China
Recommended Citation
GB/T 7714
Li,Qiuping,Wang,Guifang,Xiong,Shi Hang,et al. Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways[J]. Journal of Ethnopharmacology,2020,261.
APA Li,Qiuping,Wang,Guifang,Xiong,Shi Hang,Cao,Yuxue,Liu,Baojun,Sun,Jing,Li,Lulu,Mohammadtursun,Nabijan,Yu,Hua,Dong,Jingcheng,&Wu,Jinfeng.(2020).Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways.Journal of Ethnopharmacology,261.
MLA Li,Qiuping,et al."Bu-Shen-Fang-Chuan formula attenuates cigarette smoke-induced inflammation by modulating the PI3K/Akt-Nrf2 and NF-κB signalling pathways".Journal of Ethnopharmacology 261(2020).
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