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Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II–Induced Arthritis Through Inhibiting Multi-Target–Mediated Synovial Hyperplasia and Inflammation
Linghu,Ke Gang1; Xiong,Shi Hang1; Zhao,Guan Ding1; Zhang,Tian1; Xiong,Wei1; Zhao,Mingming1; Shen,Xiang Chun2; Xu,Wei3; Bian,Zhaoxiang4; Wang,Yitao1; Yu,Hua1,3,5
2020-08-28
Source PublicationFrontiers in Pharmacology
Volume11
Abstract

Excessive proliferation and inflammation of synovial fibroblasts accelerate and decorate the pathological process of rheumatoid arthritis (RA). Sigesbeckia orientalis L. (SO) is one of the main plant sources for Sigesbeckiae Herba (SH) which has been used traditionally in treating various forms of arthritis and rheumatic pain. However, the anti-arthritic mechanisms of SO are still not clearly understood. In this study, we investigated the therapeutic effects and the underlying mechanisms of SO against collagen type II (C II)-induced RA in rats as well as the interleukin (IL)-1β–induced human synovial SW982 and MH7A cells. For the in vivo studies, thirty-six Wistar male rats were randomly arranged to six groups based on the body weight, and then C II-induced to RA model for 15 days, followed by treatment with the 50% ethanolic extract of SO (SOE, 0.16, 0.78, and 1.56 g/kg) for 35 days. The results suggested that SOE significantly inhibited the formation of pannus (synovial hyperplasia to the articular cavity) and attenuated the cartilage damaging and bone erosion in the CIA-induced rats’ hind paw joints. Moreover, SOE decreased the production of C-reactive protein (CRP) in the serum and the expression of IL-6 and IL-1β in the joint muscles, as well as recovered the decreased regulatory T lymphocytes. The results obtained from the in vitro studies showed that SOE (50, 100, and 200 µg/ml) not only inhibited the proliferation, migration, and invasion of human synovial SW982 cells but also decreased the IL-1β–induced expression of IL-6 and IL-8 both in SW982 and MH7A cells. Besides, SOE reduced the expression of COX-2, NLRP3, and MMP9, and increased the expression of MMP2 in the IL-1β–induced SW982 cells. Furthermore, SOE blocked the activation of NF-κB and reduced the phosphorylation of MAPKs and the expression of AP-1. In conclusion, SOE attenuated the C II-induced RA through inhibiting of MAPKs/NF-κB/AP-1–mediated synovial hyperplasia and inflammation.

KeywordInflammation Mh7a Rheumatoid Arthritis Sigesbeckia Orientalisl Sw982 Synovial Hyperplasia
DOI10.3389/fphar.2020.547913
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000570446800001
Scopus ID2-s2.0-85090799060
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYu,Hua
Affiliation1.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macao
2.The Department of Pharmacology of Materia Medica,School of Pharmaceutical Sciences,Guizhou Medical University,Guiyang,China
3.College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou,China
4.School of Chinese Medicine,Hong Kong Baptist University,Kowloon Tong,China
5.HKBU Shenzhen Research Center,Shenzhen,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Linghu,Ke Gang,Xiong,Shi Hang,Zhao,Guan Ding,et al. Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II–Induced Arthritis Through Inhibiting Multi-Target–Mediated Synovial Hyperplasia and Inflammation[J]. Frontiers in Pharmacology,2020,11.
APA Linghu,Ke Gang,Xiong,Shi Hang,Zhao,Guan Ding,Zhang,Tian,Xiong,Wei,Zhao,Mingming,Shen,Xiang Chun,Xu,Wei,Bian,Zhaoxiang,Wang,Yitao,&Yu,Hua.(2020).Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II–Induced Arthritis Through Inhibiting Multi-Target–Mediated Synovial Hyperplasia and Inflammation.Frontiers in Pharmacology,11.
MLA Linghu,Ke Gang,et al."Sigesbeckia orientalis L. Extract Alleviated the Collagen Type II–Induced Arthritis Through Inhibiting Multi-Target–Mediated Synovial Hyperplasia and Inflammation".Frontiers in Pharmacology 11(2020).
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