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LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells
Xiong,Minmin1; Wu,Mengshi1; Dan Peng,1; Huang,Weijun1; Chen,Zehong2; Ke,Haoxian1; Chen,Zewen3; Song,Wu2; Zhao,Yonghua4; Xiang,Andy P.1; Zhong,Xiaomin1
2021-01
Source PublicationCell Death and Disease
ISSN2041-4889
Volume12Issue:1Pages:24
Abstract

Long non-coding RNA (lncRNA) DANCR has been reported to participate in key processes such as stem cell differentiation and tumorigenesis. In a high throughput screening for lncRNAs involved in Doxorubicin-induced apoptosis, we found DANCR was suppressed by Doxorubicin and it acted as an important repressor of apoptosis in colorectal cancer. Further studies demonstrated that DANCR promoted the oncogenic lncRNA MALAT1 expression via enhancing the RNA stability of MALAT1 to suppress apoptosis. MALAT1 could efficiently mediate the suppressive function of DANCR on apoptosis. Mechanistic studies found the RNA-binding protein QK served as an interacting partner of both DANCR and MALAT1, and the protein level of QK was subjected to the regulation by DANCR. Furthermore, QK was able to modulate the RNA stability of MALAT1, and the interaction between QK and MALAT1 was controlled by DANCR. In addition, QK could mediate the function of DANCR in regulating the expression of MALAT1 and suppressing apoptosis. These results revealed DANCR played a critical role in Doxorubicin-induced apoptosis in colorectal cancer cells, which was achieved by the interaction between DANCR and QK to enhance the expression of MALAT1.

DOI10.1038/s41419-020-03318-8
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000609618800002
Scopus ID2-s2.0-85098876737
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhong,Xiaomin
Affiliation1.Key Laboratory for Stem Cells and Tissue Engineering,Ministry of Education,Center for Stem Cell Biology and Tissue Engineering,Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou,510080,China
2.Center of Gastrointestinal Surgery,Center of Gastric Cancer,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510080,China
3.School of Biological Science,University of Reading,Reading,RG6 6AH,United Kingdom
4.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa, Macao,999078,Macao
Recommended Citation
GB/T 7714
Xiong,Minmin,Wu,Mengshi,Dan Peng,,et al. LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells[J]. Cell Death and Disease,2021,12(1):24.
APA Xiong,Minmin,Wu,Mengshi,Dan Peng,,Huang,Weijun,Chen,Zehong,Ke,Haoxian,Chen,Zewen,Song,Wu,Zhao,Yonghua,Xiang,Andy P.,&Zhong,Xiaomin.(2021).LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells.Cell Death and Disease,12(1),24.
MLA Xiong,Minmin,et al."LncRNA DANCR represses Doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells".Cell Death and Disease 12.1(2021):24.
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