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Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
Zhu,Daoming1,3; Duo,Yanhong4; Suo,Meng3; Zhao,Yonghua5; Xia,Ligang1; Zheng,Zheng2; Li,Yang1; Tang,Ben Zhong2
2020-08-10
Source PublicationAngewandte Chemie - International Edition
ISSN1433-7851
Volume59Issue:33Pages:13836-13843
Abstract

The development of novel photosensitizing agents with aggregation-induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor-exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor-exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen-based PDT systems and underscores the potential clinical value of AIEgens.

KeywordDexamethasone Exosome/aiegen Hybrid Nanovesicles Photodynamic Therapy Tumor Penetration Tumor Vascular Normalization
DOI10.1002/anie.202003672
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000539396700001
Scopus ID2-s2.0-85085750305
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Cited Times [WOS]:74   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi,Yang
Affiliation1.Department of Gastrointestinal Surgery,Second Clinical Medical College of Jinan University,Shenzhen People's Hospital,Shenzhen,518020,China
2.Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,Institute for Advanced Study,Department of Chemical and Biological Engineering and Division of Life Science,The Hong Kong University of Science and Technology (HKUST),Kowloon,Clear Water Bay,China
3.Department of Electronic Science and Technology,School of Physics and Technology,Wuhan University,Wuhan,430072,China
4.Department of Microbiology,Tumor and Cell Biology,Karolinska Institute,Stockholm,17177,Sweden
5.State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,China
Recommended Citation
GB/T 7714
Zhu,Daoming,Duo,Yanhong,Suo,Meng,et al. Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy[J]. Angewandte Chemie - International Edition,2020,59(33):13836-13843.
APA Zhu,Daoming,Duo,Yanhong,Suo,Meng,Zhao,Yonghua,Xia,Ligang,Zheng,Zheng,Li,Yang,&Tang,Ben Zhong.(2020).Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy.Angewandte Chemie - International Edition,59(33),13836-13843.
MLA Zhu,Daoming,et al."Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy".Angewandte Chemie - International Edition 59.33(2020):13836-13843.
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