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Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo
Wang,Xingshun1,2; Feng,Weimin1; Peng,Cheng1,2; Chen,Shiyun1; Ji,Hongbin3,4,5,6; Zhong,Hanbing1; Ge,Wei2; Zhang,Yandong1,7
Source PublicationCancer Science

Ras has been found to be mutated in 30% of non-small cell lung cancers, and its mutation has been regarded as a causal factor underlying tumorigenesis. However, no successful medicine has been developed so far to inhibit Ras for lung cancer treatment. We have previously identified DHX33 as a Ras downstream effector, promoting cell cycle progression and cell growth. In this study, with the K-Ras (G12D);DHX33 (lox/lox) mouse model, we discovered that genetic ablation of DHX33 inhibited tumor development. We further found that ablation of DHX33 altered the expression of nearly 2000 genes which are critical in cancer development such as cell cycle, apoptosis, glycolysis, Wnt signaling, and cell migration. Our study for the first time demonstrates the pivotal role of the DHX33 in Ras-driven lung cancer development in vivo and highlights that pharmacological targeting DHX33 can be a feasible option in treating Ras-mutant lung cancers.

KeywordDhx33 Lung Cancer Oncogene Ras Rna Helicase
URLView the original
Indexed BySCIE
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000562037800001
Scopus ID2-s2.0-85089735051
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhang,Yandong
Affiliation1.Department of Biology,Southern University of Science and Technology,Shenzhen,China
2.Faculty of Health Sciences,University of Macau,Macao
3.State Key Laboratory of Cell Biology,Shanghai,China
4.CAS Center for Excellence in Molecular Cell Science,Shanghai,China
5.Innovation Center for Cell Signaling Network,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China
6.School of Life Science and Technology,Shanghai Tech University,Shanghai,China
7.KeYe Life Technologies Co.,Ltd,Shenzhen,China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Wang,Xingshun,Feng,Weimin,Peng,Cheng,et al. Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo[J]. Cancer Science,2020,111(10):3564-3575.
APA Wang,Xingshun,Feng,Weimin,Peng,Cheng,Chen,Shiyun,Ji,Hongbin,Zhong,Hanbing,Ge,Wei,&Zhang,Yandong.(2020).Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.Cancer Science,111(10),3564-3575.
MLA Wang,Xingshun,et al."Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo".Cancer Science 111.10(2020):3564-3575.
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