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A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy
Lu,Guang1; Wang,Liming1; Zhou,Jing1; Liu,Wei2; Shen,Han Ming1,3
Source PublicationTrends in Cell Biology

Autophagy and the ubiquitin-proteasome system (UPS) are two major pathways for protein degradation. The cullin-RING E3 ligases (CRLs) are the largest E3 ligase family and have key biological functions in maintaining protein homeostasis. We provide an updated review of the interactions between CRLs and autophagy, focusing on the regulatory effects of CRLs on the core autophagy machinery that consists of several autophagy-related protein (ATG) complexes and their key upstream signaling pathways. The involvement of such functional interactions in health and disease is also discussed. Understanding the role of CRLs in autophagy is helpful for the development of therapeutic strategies for diseases in which CRLs and autophagy are dysregulated, such as cancer and neurodegenerative conditions.

KeywordAutophagy Cancer Cullin-ring E3 Ligases Mtorc1 Neddylation Ubiquitination
URLView the original
Indexed BySCIE
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000651151800004
Scopus ID2-s2.0-85100623388
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorShen,Han Ming
Affiliation1.Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore
2.Department of Biochemistry,School of Medicine,Zhejiang University,Hangzhou,China
3.Faculty of Health Sciences,University of Macau,Macau,China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Lu,Guang,Wang,Liming,Zhou,Jing,et al. A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy[J]. Trends in Cell Biology,2021.
APA Lu,Guang,Wang,Liming,Zhou,Jing,Liu,Wei,&Shen,Han Ming.(2021).A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy.Trends in Cell Biology.
MLA Lu,Guang,et al."A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy".Trends in Cell Biology (2021).
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