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Roles of vitamins in stem cells
Godoy-Parejo,Carlos1; Deng,Chunhao1; Zhang,Yumeng1; Liu,Weiwei1,2; Chen,Guokai1,2,3
Source PublicationCellular and Molecular Life Sciences

Stem cells can differentiate to diverse cell types in our body, and they hold great promises in both basic research and clinical therapies. For specific stem cell types, distinctive nutritional and signaling components are required to maintain the proliferation capacity and differentiation potential in cell culture. Various vitamins play essential roles in stem cell culture to modulate cell survival, proliferation and differentiation. Besides their common nutritional functions, specific vitamins are recently shown to modulate signal transduction and epigenetics. In this article, we will first review classical vitamin functions in both somatic and stem cell cultures. We will then focus on how stem cells could be modulated by vitamins beyond their nutritional roles. We believe that a better understanding of vitamin functions will significantly benefit stem cell research, and help realize their potentials in regenerative medicine.

KeywordVitamin Cell Culture Vitamin a Vitamin B3 Vitamin c Vitamin e Embryogenesis Stem Cells
URLView the original
WOS IDWOS:000493632700001
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
Indexed BySCIE
Scopus ID2-s2.0-85074719324
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeReview article
CollectionFaculty of Health Sciences
Corresponding AuthorChen,Guokai
Affiliation1.Centre of Reproduction,Development and Aging,Faculty of Health Sciences,University of Macau,Taipa,Macao
2.Bioimaging and Stem Cell Core Facility,Faculty of Health Sciences,University of Macau,Taipa,Macao
3.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Taipa,Macao
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Godoy-Parejo,Carlos,Deng,Chunhao,Zhang,Yumeng,et al.Roles of vitamins in stem cells[J].Cellular and Molecular Life Sciences.2020.77(9):1771-1791.
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