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Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region
Tang,Chao Tian1; Chua,Ee Cheong1; Chew,Qian Hui1; He,Yan Ling2; Si,Tian Mei3; Chiu,Helen F.K.4; Xiang,Yu Tao5; Kato,Takahiro A.6; Kanba,Shigenobu6; Shinfuku,Naotaka7; Lee,Min Soo8; Park,Seon Cheol9; Park,Yong Chon10; Chong,Mian Yoon11; Lin,Shih Ku12; Yang,Shu Yu12; Tripathi,Adarsh13; Avasthi,Ajit14; Grover,Sandeep14; Kallivayalil,Roy A.15; Udomratn,Pichet16; Chee,Kok Yoon17; Tanra,Andi J.18; Rabbani,Md Golam19; Javed,Afzal20; Kathiarachchi,Samudra21; Waas,Dulshika21; Myint,Wing Aung22; Sartorius,Norman23; Tran,Van Cuong24; Nguyen,Kim Viet24; Tan,Chay Hoon25; Baldessarini,Ross J.26; Sim,Kang1
Source PublicationAsia-Pacific Psychiatry

Introduction: Patterns of clinical use of long-acting injectable (LAI) antipsychotic drugs in many countries, especially in Asia, for treatment of patients diagnosed with chronic psychotic disorders including schizophrenia are not well established. Methods: Within an extensive research consortium, we evaluated prescription rates for first- (FGA) and second-generation antipsychotic (SGA) LAI drugs and their clinical correlates among 3557 subjects diagnosed with schizophrenia across 15 Asian countries and region. Results: Overall, an average of 17.9% (638/3557; range: 0.0%-44.9%) of treated subjects were prescribed LAI antipsychotics. Those given LAI vs orally administered agents were significantly older, had multiple hospitalizations, received multiple antipsychotics more often, at 32.4% higher doses, were more likely to manifest disorganized behavior or aggression, had somewhat superior psychosocial functioning and less negative symptoms, but were more likely to be hospitalized, with higher BMI, and more tremor. Being prescribed an FGA vs SGA LAI agent was associated with male sex, aggression, disorganization, hospitalization, multiple antipsychotics, higher doses, with similar risks of adverse neurological or metabolic effects. Rates of use of LAI antipsychotic drugs to treat patients diagnosed with schizophrenia varied by more than 40-fold among Asian countries and given to an average of 17.9% of treated schizophrenia patients. We identified the differences in the clinical profiles and treatment characteristics of patients who were receiving FGA-LAI and SGA-LAI medications. Discussion: These findings behoove clinicians to be mindful when evaluating patients' need to be on LAI antipsychotics amidst multifaceted considerations, especially downstream adverse events such as metabolic and extrapyramidal side effects.

KeywordAntipsychotic Drugs Long-acting Injectable Schizophrenia
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Indexed BySCIE ; SSCI
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000536350900001
Scopus ID2-s2.0-85085649044
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSim,Kang
Affiliation1.Institute of Mental Health,Buangkok Green Medical Park,Singapore,Singapore
2.Department of Psychiatric Epidemiology,Shanghai Mental Health Center,Shanghai,China
3.Institute of Mental Health,Peking University,Beijing,China
4.Department of Psychiatry,Chinese University of Hong Kong,Hong Kong
5.Centre for Cognition and Brain Sciences,University of Macau,Macao
6.Department of Neuropsychiatry,Graduate School of Medicine,Kyushu University,Fukuoka,Japan
7.Department of Psychiatry,Kobe University,Kobe,Japan
8.Department of Psychiatry,College of Medicine,Korea University,Seoul,South Korea
9.Department of Psychiatry,Inje University Haeundae Paik Hospital,Busan,South Korea
10.Department of Neuropsychiatry,Hanyang University Guri Hospital,Guri,South Korea
11.Department of Psychiatry,Kaoshiung Chang Gung Memorial Hospital and Chang Gung University School of Medicine,Kaohsiung,Taiwan
12.Department of Pharmacy,Taipei City Hospital and Fu Jen University,Taipei,Taiwan
13.Department of Psychiatry,King George's Medical University,Lucknow,India
14.Department of Psychiatry,Post Graduate Institute of Medical Education and Research (PGIMER),Chandigarh,India
15.Department of Psychiatry,Pushpagiri Institute of Medical Sciences,Tiruvalla,India
16.Department of Psychiatry,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand
17.Department of Psychiatry & Mental Health,Tunku Abdul Rahman Institute of Neurosciences,Kuala Lumpur,Malaysia
18.Department of Psychiatry,Hasanuddin University Faculty of Medicine,Makassar,Indonesia
19.Bangladesh Association of Psychiatrists,Dhaka,Bangladesh
20.Pakistan Psychiatric Research Center,Fountain House,Lahore,Pakistan
21.Department of Psychiatry,University of Sri Jayewardenepura,Nugegoda,Sri Lanka
22.Mental Health Society,Myanmar Medical Association,Yangon,Myanmar
23.Association for the Improvement of Mental Health Programmes,Geneva,Switzerland
24.Vietnam Psychiatric Association (VPA),Thuong Tin, Hanoi,Viet Nam
25.Department of Pharmacology,National University Hospital,Singapore,Singapore
26.International Consortium for Mood & Psychotic Disorder Research,McLean Hospital,Belmont,United States
Recommended Citation
GB/T 7714
Tang,Chao Tian,Chua,Ee Cheong,Chew,Qian Hui,et al. Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region[J]. Asia-Pacific Psychiatry,2020,12(4).
APA Tang,Chao Tian.,Chua,Ee Cheong.,Chew,Qian Hui.,He,Yan Ling.,Si,Tian Mei.,Chiu,Helen F.K..,Xiang,Yu Tao.,Kato,Takahiro A..,Kanba,Shigenobu.,Shinfuku,Naotaka.,Lee,Min Soo.,Park,Seon Cheol.,Park,Yong Chon.,Chong,Mian Yoon.,Lin,Shih Ku.,Yang,Shu Yu.,Tripathi,Adarsh.,Avasthi,Ajit.,Grover,Sandeep.,...&Sim,Kang.(2020).Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region.Asia-Pacific Psychiatry,12(4).
MLA Tang,Chao Tian,et al."Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region".Asia-Pacific Psychiatry 12.4(2020).
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