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Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study
Lim,Wai Kwong1; Chew,Qian Hui1; He,Yan Ling2; Si,Tian Mei3; Chiu,Fung Kum Helen4; Xiang,Yu Tao5; Kato,Takahiro A.6; Kanba,Shigenobu6; Shinfuku,Naotaka7; Lee,Min Soo8; Park,Seon Cheol9; Park,Yong Chon10; Chong,Mian Yoon11; Lin,Shih Ku12; Yang,Shu Yu12; Tripathi,Adarsh13; Avasthi,Ajit14; Grover,Sandeep14; Kallivayalil,Roy Abraham15; Udomratn,Pichet16; Chee,Kok Yoon17; Tanra,Andi J.18; Rabbani,Md Golam19; Javed,Afzal20; Kathiarachchi,Samudra21; Waas,Dulshika21; Myint,Wing Aung22; Sartorius,Norman23; Tran,Van Cuong24; Nguyen,Kim Viet24; Tan,Chay Hoon25; Baldessarini,Ross J.26; Sim,Kang1
Source PublicationHuman Psychopharmacology

Objective: Studies examining coprescription and dosages of mood stabilizers (MSs) with antipsychotics for psychotic disorders are infrequent. Based on sparse extant data and clinical experience, we hypothesized that adjunctive MS use would be associated with certain demographic (e.g., younger age), clinical factors (e.g., longer illness duration), and characteristics of antipsychotic treatment (e.g., multiple or high antipsychotic doses). Methods: Within an Asian research consortium focusing on pharmaco-epidemiological factors in schizophrenia, we evaluated rates of MS coprescription, including high doses (>1000 mg/day lithium-equivalents) and clinical correlates. Results: Among 3557 subjects diagnosed with schizophrenia in 14 Asian countries, MSs were coprescribed with antipsychotics in 13.6% (n = 485) of the sample, with 10.9% (n = 53) on a high dose. Adjunctive MS treatment was associated (all p < 0.005) with demographic (female sex and younger age), setting (country and hospitalization), illness (longer duration, more hospitalizations, non-remission of illness, behavioral disorganization, aggression, affective symptoms, and social–occupational dysfunction), and treatment-related factors (higher antipsychotic dose, multiple antipsychotics, higher body mass index, and greater sedation). Patients given high doses of MSs had a less favorable illness course, more behavioral disorganization, poorer functioning, and higher antipsychotic doses. Conclusions: Schizophrenia patients receiving adjunctive MS treatment in Asian psychiatric centers are more severely ill and less responsive to simpler treatment regimens.

KeywordAdjunctive Treatment Asia Mood Stabilizers Schizophrenia
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Indexed BySCIE ; SSCI
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000559354100001
Scopus ID2-s2.0-85088877136
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorSim,Kang
Affiliation1.Institute of Mental Health,Singapore,Singapore
2.Department of Psychiatric Epidemiology,Shanghai Mental Health Center,Shanghai,China
3.Institute of Mental Health,Peking University,Beijing,China
4.Department of Psychiatry,Chinese University of Hong Kong,Hong Kong
5.Faculty of Health Sciences,University of Macau,Macao
6.Department of Neuropsychiatry,Graduate School of Medicine,Kyushu University,Fukuoka,Japan
7.Department of Psychiatry,Kobe University,Kobe,Japan
8.Department of Psychiatry,College of Medicine,Korea University,Seoul,South Korea
9.Department of Psychiatry,Inje University Haeundae Paik Hospital,Busan,South Korea
10.Department of Psychiatry,Hanyang University,Seoul,South Korea
11.Department of Psychiatry,Kaoshiung Chang Gung Memorial Hospital and Chang Gung University School of Medicine,Kaohsiung,Taiwan
12.Psychiatric Center,Taipei City Hospital,Taipei,Taiwan
13.Department of Psychiatry,King George's Medical University,Lucknow,India
14.Department of Psychiatry,Post Graduate Institute of Medical Education and Research (PGIMER),Chandigarh,India
15.Pushpagiri Institute of Medical Sciences,Tiruvalla,India
16.Department of Psychiatry,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand
17.Department of Psychiatry & Mental Health,Tunku Abdul Rahman Institute of Neurosciences,Kuala Lumpur,Malaysia
18.Department of Psychiatry,Hasanuddin University Faculty of Medicine,Makassar,Indonesia
19.Bangladesh Association of Psychiatrists,Bangladesh,Bangladesh
20.Pakistan Psychiatric Research Center,Fountain House,Lahore,Pakistan
21.Department of Psychiatry,University of Sri Jayewardenepura,Nugegoda,Sri Lanka
22.Mental Health Society,Myanmar Medical Association,Yangon,Myanmar
23.Association for the Improvement of Mental Health Programmes,Geneva,Switzerland
24.Vietnam Psychiatric Association (VPA),Hanoi,Viet Nam
25.Department of Pharmacology,National University Hospital,Singapore,Singapore
26.International Consortium for Mood & Psychotic Disorder Research,McLean Hospital,Belmont,United States
Recommended Citation
GB/T 7714
Lim,Wai Kwong,Chew,Qian Hui,He,Yan Ling,et al. Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study[J]. Human Psychopharmacology,2020,35(6):1-7.
APA Lim,Wai Kwong.,Chew,Qian Hui.,He,Yan Ling.,Si,Tian Mei.,Chiu,Fung Kum Helen.,Xiang,Yu Tao.,Kato,Takahiro A..,Kanba,Shigenobu.,Shinfuku,Naotaka.,Lee,Min Soo.,Park,Seon Cheol.,Park,Yong Chon.,Chong,Mian Yoon.,Lin,Shih Ku.,Yang,Shu Yu.,Tripathi,Adarsh.,Avasthi,Ajit.,Grover,Sandeep.,Kallivayalil,Roy Abraham.,...&Sim,Kang.(2020).Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study.Human Psychopharmacology,35(6),1-7.
MLA Lim,Wai Kwong,et al."Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study".Human Psychopharmacology 35.6(2020):1-7.
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