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Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials
Cai,Dong Bin1; Zheng,Wei2; Zhang,Qing E.3; Ng,Chee H.4; Ungvari,Gabor S.5,6; Huang,Xiong2; Xiang,Yu Tao7
Source PublicationPsychiatric Quarterly

Neuroinflammation appears to be associated with the neurobiology of depression, and treatments targeting inflammation have shown promising results in depression. This meta-analysis examined the efficacy and safety of minocycline, an anti-inflammatory drug, for the treatment of depressive symptoms. A systematic electronic literature search was independently conducted by two investigators. Standardized mean differences (SMDs) and risk ratio (RR) with their 95% confidence interval (CI) were calculated using a random-effect model. Four RCTs (n = 211) were identified for meta-analysis. Minocycline showed a significant trend of improvement in depressive symptoms compared to placebo [4 RCTs, n = 190, SMD: -0.54 (95%CI:-1.12, 0.04), P = 0.07; I = 73%]. Subgroup analyses showed that minocycline was superior to placebo in improving depressive symptoms in studies of unipolar depression (3 RCTs, n = 151, SMD: -0.77 (95%CI:-1.32, −0.22), P = 0.006; I = 60%) and in studies using minocycline monotherapy [SMD: -1.06 (95%CI:-1.68, −0.44), P = 0.0008]. The rates of discontinuation due to any reasons [RR: 1.48 (95%CI: 0.79, 2.77), P = 0.22, I = 0%] and adverse drug reactions [RR: 0.32 to 1.98 (95%CI: 0.03, 14.74), P = 0.19 to 0.84, I = 0% to 31%] were similar between minocycline and placebo. Minocycline appears to be effective and well-tolerated in ameliorating depressive symptoms in unipolar depression. Future large RCTs with sufficient duration is needed to confirm the positive effects of minocycline in treating depressive symptoms.

KeywordDepressive Symptoms Meta-analysis Minocycline Remission Response
URLView the original
Indexed BySSCI
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000537442300014
Scopus ID2-s2.0-85078203101
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang,Yu Tao
Affiliation1.Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,China
2.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital),Guangzhou,China
3.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing,China
4.Department of Psychiatry,The Melbourne Clinic and St Vincent’s Hospital,University of Melbourne,Richmond,Australia
5.Department of Psychiatry,University of Notre Dame Australia,Fremantle,Australia
6.Division of Psychiatry,School of Medicine,University of Western Australia,Perth,Australia
7.Center for Cognition and Brain Sciences,University of Macau,Macao
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Cai,Dong Bin,Zheng,Wei,Zhang,Qing E.,et al. Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials[J]. Psychiatric Quarterly,2020,91(2):451-461.
APA Cai,Dong Bin,Zheng,Wei,Zhang,Qing E.,Ng,Chee H.,Ungvari,Gabor S.,Huang,Xiong,&Xiang,Yu Tao.(2020).Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials.Psychiatric Quarterly,91(2),451-461.
MLA Cai,Dong Bin,et al."Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials".Psychiatric Quarterly 91.2(2020):451-461.
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