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Clozapine prescription pattern in patients with schizophrenia in Asia: The REAP survey (2016)
Xu,Shi Wei1,23; Dong,Min2; Zhang,Qinge3; Yang,Shu Yu4; Chen,Lian Yu5; Sim,Kang6; He,Yan Ling7; Chiu,Helen FK8; Sartorius,Norman9; Tan,Chay Hoon10; Chong,Mian Yoon11; Shinfuku,Naotaka12; Lin,Shih Ku13; Ng,Chee H.14; Ungvari,Gabor S.15,16; Najoan,Eunice17; Kallivayalil,Roy Abraham18; Jamaluddin,Ruzita19; Javed,Afzal20; Iida,Hitoshi21; Swe,Thiha22; Zhang,Bin1,23; Xiang,Yu Tao2
Source PublicationPsychiatry Research

Clozapine is an effective antipsychotic medication for treatment resistant schizophrenia and is widely used in Asian countries. This study investigated clozapine prescription patterns and their associated factors in Asian countries and territories based on the database of the Research on Asian Psychotropic prescription study (REAP) conducted in 2016. Demographic and clinical information of 3744 schizophrenia patients in 15 Asian countries and territories was collected with a standardized data collection form. In total, 18.4% of the sample received clozapine, ranging from 2.6% in Japan to 32.3% in Hong Kong. Binary logistic regression analysis revealed that higher antipsychotic dose (OR = 1.002, P < 0.001), less frequent first admission in the sample (OR = 0.6, P < 0.001), more severe negative symptoms (OR = 1.4, P = 0.001) and less first generation antipsychotics (FGAs) (OR = 0.2, P < 0.001) were independently and significantly associated with clozapine prescription. Clozapine is frequently and increasingly prescribed for schizophrenia in Asia, with large variation across countries and territories. Given the diverse prescription patterns of clozapine found in Asian countries/territories, the clinical rationale of clozapine prescription needs careful consideration in Asia with more local input.

KeywordSchizophrenia Asia Prescription Patterns Clozapine
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Indexed BySCIE ; SSCI
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000528191200008
Scopus ID2-s2.0-85062920203
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Co-First AuthorXu,Shi Wei; Dong,Min
Corresponding AuthorZhang,Bin; Xiang,Yu Tao
Affiliation1.Department of Psychiatry and Psychology,Southern Medical University Nanfang Hospital,China
2.Unit of Psychiatry,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Taipa,China
3.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection,Capital Medical University,School of Mental Health,China
4.Department of Pharmacy,Taipei City Hospital,Taipei,Taiwan
5.Taipei City Psychiatric Center,Taipei City Hospital,Taipei,Taiwan
6.Institute of Mental Health,Buangkok Green Medical Park,Singapore
7.Department of Psychiatric Epidemiology,Shanghai Mental Health Center,China
8.Department of Psychiatry,Chinese University of Hong Kong,China
9.Association for the Improvement of Mental Health Programmes,Geneva,Switzerland
10.Department of Pharmacology,National University of Singapore,Singapore
11.Chiayi Chang Gung Memorial Hospital and School of Medicine,Chang Gung University,Chiayi,Taiwan
12.International Center for Medical Research,Kobe University School of Medicine,Kobe,Japan
13.Department of Psychiatry,School of Medicine,Taipei Medical University,Taipei,Taiwan
14.Department of Psychiatry,University of Melbourne,Melbourne,Australia
15.University of Notre Dame Australia,Fremantle,Australia
16.Division of Psychiatry,School of Medicine,University of Western Australia,Australia
17.Mintoharjo Hospital,Jakarta,Indonesia
18.Pushpagiri Institute of Medical Sciences,Tiruvalla,India
19.Department of Psychiatry & Mental Health,Hospital Tuanku Fauziah,Kangar,Malaysia
20.Pakistan Psychiatric Research Centre,Fountain House,Lahore,Pakistan
21.Department of Psychiatry,Faculty of Medicine,Fukuoka University,Fukuoka,Japan
22.Department of Mental Health,University of Medicine,Magway,Myanmar
23.Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence,Guangzhou,China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Xu,Shi Wei,Dong,Min,Zhang,Qinge,et al. Clozapine prescription pattern in patients with schizophrenia in Asia: The REAP survey (2016)[J]. Psychiatry Research,2020,287.
APA Xu,Shi Wei.,Dong,Min.,Zhang,Qinge.,Yang,Shu Yu.,Chen,Lian Yu.,Sim,Kang.,He,Yan Ling.,Chiu,Helen FK.,Sartorius,Norman.,Tan,Chay Hoon.,Chong,Mian Yoon.,Shinfuku,Naotaka.,Lin,Shih Ku.,Ng,Chee H..,Ungvari,Gabor S..,Najoan,Eunice.,Kallivayalil,Roy Abraham.,Jamaluddin,Ruzita.,Javed,Afzal.,...&Xiang,Yu Tao.(2020).Clozapine prescription pattern in patients with schizophrenia in Asia: The REAP survey (2016).Psychiatry Research,287.
MLA Xu,Shi Wei,et al."Clozapine prescription pattern in patients with schizophrenia in Asia: The REAP survey (2016)".Psychiatry Research 287(2020).
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