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Transcriptome analysis reveals lncRNA-mediated complex regulatory network response to DNA damage in the liver tissue of Rattus norvegicus
Huang C.; Leng D.; Lei K.C.; Sun S.; Zhang X.D.
2019
Source PublicationJournal of Cellular Physiology
ISSN0021-9541
Volume234Issue:12Pages:23216-23231
Abstract

DNA is prone to damages, which would result in genetic disorders and enhance risk of tumorigenesis. Hence, understanding the molecular mechanisms of DNA damage and repair will provide deep insights into tumorigenesis, carcinogenesis as well as the corresponding treatments. Aiming at investigating potential long noncoding RNAs (lncRNAs) response against DNA damage, we performed a comprehensive transcriptomic analysis based on RNA sequencing data of the liver tissue from Rattus norvegicus, in which DNA damage was induced using aflatoxin B1, ifosfamide and N-nitrosodimethylamine. Through our analyses, numerous novel lncRNAs are identified for the first time, and differential network analysis discloses lncRNA-mediated regulatory networks related to DNA-damage response. The result shows that these DNA-damage-inducing chemicals might disrupt many lncRNA-mediated interactions involved in diverse biological processes and pathways, for example, immune function and cell adhesion. In contrast, the host might also activate a few RNA interactions in response to DNA damage, involving response to drug and regulation of cell cycle.

KeywordDifferentially Expressed Transcript Dna Damage Lncrnas Network Rna Sequencing
DOI10.1002/jcp.28889
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCell Biology ; Physiology
WOS SubjectCell Biology ; Physiology
WOS IDWOS:000484376600150
The Source to ArticleScopus
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhang X.D.
AffiliationFaculty of Health Sciences, University of Macau, Taipa, Macau
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Huang C.,Leng D.,Lei K.C.,et al. Transcriptome analysis reveals lncRNA-mediated complex regulatory network response to DNA damage in the liver tissue of Rattus norvegicus[J]. Journal of Cellular Physiology,2019,234(12):23216-23231.
APA Huang C.,Leng D.,Lei K.C.,Sun S.,&Zhang X.D..(2019).Transcriptome analysis reveals lncRNA-mediated complex regulatory network response to DNA damage in the liver tissue of Rattus norvegicus.Journal of Cellular Physiology,234(12),23216-23231.
MLA Huang C.,et al."Transcriptome analysis reveals lncRNA-mediated complex regulatory network response to DNA damage in the liver tissue of Rattus norvegicus".Journal of Cellular Physiology 234.12(2019):23216-23231.
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