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An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion
Wang,Yuan; Li,Jiajia; Li,Jingjing; Li,Peipei; Wang,Li; Di,Lijun
2020-12-02
Source PublicationFrontiers in Genetics
ISSN1664-8021
Volume11
Abstract

Cancer is characterized by dysregulation at multiple levels, such as gene transcription. Enhancers are well-studied transcription regulators that can enhance target transcripts through DNA loop formation mediated by chromosome folding. The gain or loss of the interaction between an enhancer and its target gene has a critical effect on gene expression. In this study, we analyzed GRO-seq data to identify active enhancers from seven common cancer cell lines and studied the function of these enhancers across multiple cancer types. By constructing an “enhancer effect score” (EES), we found a significant correlation between EES and tumor-infiltrating lymphocytes (TILs) in prostate cancer. Further analysis revealed that androgen receptor (AR) plays an important role in regulating the immune checkpoint gene PVR via its enhancer. These results suggest that AR contributes to prostate cancer aggressiveness by promoting cancer cell immune evasion.

KeywordAndrogen Receptor Enhancer Gro-seq Immune Evading Prostate Cancer
DOI10.3389/fgene.2020.595550
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000598867500001
Scopus ID2-s2.0-85097675298
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorDi,Lijun
AffiliationCancer Center,Faculty of Health Sciences,University of Macau,Macao
First Author AffilicationCancer Centre
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Wang,Yuan,Li,Jiajia,Li,Jingjing,et al. An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion[J]. Frontiers in Genetics,2020,11.
APA Wang,Yuan,Li,Jiajia,Li,Jingjing,Li,Peipei,Wang,Li,&Di,Lijun.(2020).An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion.Frontiers in Genetics,11.
MLA Wang,Yuan,et al."An Enhancer-Based Analysis Revealed a New Function of Androgen Receptor in Tumor Cell Immune Evasion".Frontiers in Genetics 11(2020).
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