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New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy
Ma,Rui1,2; Kwok,Hang Fai1,2
2022-05
Source PublicationSeminars in Cancer Biology
ISSN1044-579X
Volume80Pages:356-369
Abstract

Due to advances in detection and treatment of cancer, especially the rise in the targeted therapy, the five-year relative survival rate of all cancers has increased significantly. However, according to the analysis of the survival rate of cancer patients in 2019, the survival rate of most cancers is still less than five years. Therefore, to combat complex cancer and further improve the 5-year survival rate of cancer patients, it is necessary to develop some new anticancer drugs. Because of the adaptive evolution of toxic species for millions of years, the venom sac is a "treasure bank", which has millions of biomolecules with high affinity and stability awaiting further development. Complete utilization of venom-based and bacteria-derived drugs in the market is still staggering because of incomplete understanding regarding their mode of action. In this review, we focused on the currently identified targets for anticancer effects based on venomous and bacterial biomolecules, such as ion channels, membrane non-receptor molecules, integrins, and other related target molecules. This review will serve as the key for exploring the molecular mechanisms behind the anticancer potential of venom-based and bacteria-derived drugs and will also lay the path for the development of anticancer targeted therapy.

KeywordAnticancer Ion Channels Targeted Therapy Targets Venom
DOI10.1016/j.semcancer.2020.08.010
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000767186700007
Scopus ID2-s2.0-85089895841
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Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Translational Medicine
Faculty of Health Sciences
Cancer Centre
Corresponding AuthorKwok,Hang Fai
Affiliation1.Cancer Center,Faculty of Health Sciences,University of Macau,Taipa,Macao
2.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Taipa,Macao
First Author AffilicationCancer Centre;  Faculty of Health Sciences
Corresponding Author AffilicationCancer Centre;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Ma,Rui,Kwok,Hang Fai. New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy[J]. Seminars in Cancer Biology,2022,80:356-369.
APA Ma,Rui,&Kwok,Hang Fai.(2022).New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy.Seminars in Cancer Biology,80,356-369.
MLA Ma,Rui,et al."New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy".Seminars in Cancer Biology 80(2022):356-369.
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