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Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment
Zhang,Zhan; Sang,Wei; Xie,Lisi; Li,Wenxi; Li,Bei; Li,Jie; Tian,Hao; Yuan,Zhen; Zhao,Qi; Dai,Yunlu
2021-01-25
Source PublicationAngewandte Chemie - International Edition
ISSN1433-7851
Volume60Issue:4Pages:1967-1975
Abstract

Engineering multifunctional nanoplatforms with high therapeutic benefits has become a promising strategy for intractable cancer treatment. A novel polyphenol-based nanocomplex was designed to evoke highly efficacious cancer immunosurveillance while localizing therapy on the primary tumor and to minimize systemic side effects. This nanocomplex is prepared via metal–polyphenol coordination by encapsulating a natural polyphenol, gossypol, and a newly synthesized polyphenol derivative, polyethylene glycol-Chlorin e6 (Ce6). The combination of gossypol from cotton and the photosensitizer Ce6 can induce chemotherapeutic/photodynamic immunogenic cancer cell death upon laser irradiation, which is supported by a rich maturation of dendritic cells, concentrated secretion of inflammatory cytokines, and significant inhibition of distant untreated tumors. Finally, an assistance of the programmed-cell-death ligand-1 checkpoint-blockade immunotherapy can enhance the anti-tumor immune stimulation of our nanoplatform to a higher level.

KeywordCombination Cancer Therapy Gossypol Metal–polyphenol Coordination Nanomedicine Pd-l1 Checkpoint Blockade
DOI10.1002/anie.202013406
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000591755800001
Scopus ID2-s2.0-85096719801
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDai,Yunlu
AffiliationCancer Centre and Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,999078,Macao
First Author AffilicationCancer Centre
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Zhang,Zhan,Sang,Wei,Xie,Lisi,et al. Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment[J]. Angewandte Chemie - International Edition,2021,60(4):1967-1975.
APA Zhang,Zhan,Sang,Wei,Xie,Lisi,Li,Wenxi,Li,Bei,Li,Jie,Tian,Hao,Yuan,Zhen,Zhao,Qi,&Dai,Yunlu.(2021).Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment.Angewandte Chemie - International Edition,60(4),1967-1975.
MLA Zhang,Zhan,et al."Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment".Angewandte Chemie - International Edition 60.4(2021):1967-1975.
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