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Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder
Lu,Fengmei1,2; Wang,Mengyun3; Xu,Shiyang3,4; Chen,Heng5; Yuan,Zhen3,4; Luo,Lizhu1; Wang,Xiuli1; Zhang,Jiang6; Dai,Jing1; Wang,Xiaoping7,8; Chen,Huafu1,2; Zhou,Jiansong7,8
Source PublicationBrain Imaging and Behavior

Conduct disorder (CD) is a common psychiatric disorder defined by a repetitive and persistent pattern of aggressive and antisocial behaviors. Although numerous task-based and resting-state functional magnetic resonance imaging (rsfMRI) studies have emphasized the disrupted functional connectivity in CD, the CD-related alterations in functional interactions between the bilateral cerebral hemispheres are rarely investigated directly. In this study, a voxel-mirrored homotopic connectivity (VMHC) method based on rsfMRI was employed for the first time to examine the abnormalities of interhemispheric functional connectivity in patients with CD. The VMHC was compared between eighteen pure CD patients and eighteen typically developing (TD) healthy controls. In CD patients, reduced homotopic connectivity was observed relative to TDs in the middle occipital gyrus (MOG), pre- and postcentral gyrus, rolandic operculum and paracentral lobe (PCL) which were the components of visual and motor networks. Furthermore, the VMHC of the MOG and PCL was found to be negatively correlated with clinical scores in the CD group. Moreover, the regions with altered VMHC exhibited a relative good and robust ability to discriminate CD patients from TDs. This study provided a novel angle to identify the important role of interhemispheric coordination in the pathophysiology underlying CD and further indicated that the aberrant homotopic connectivity could be a potential clinical neural marker for CD diagnosis.

KeywordConduct Disorder Interhemispheric Coordination Resting-state Functional Magnetic Resonance Imaging Voxel-mirrored Homotopic Connectivity
URLView the original
Indexed BySCIE
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000545293200001
Scopus ID2-s2.0-85087485275
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
Faculty of Health Sciences
Corresponding AuthorZhou,Jiansong
Affiliation1.The Clinical Hospital of Chengdu Brain Science Institute,MOE Key Lab for Neuroinformation,University of Electronic Science and Technology of China,Chengdu,China
2.MOE Key Lab for Neuroinformation,High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province,University of Electronic Science and Technology of China,Chengdu,610054,China
3.Faculty of Health Sciences,University of Macau,Macao
4.Centre for Cognitive and Brain Sciences,University of Macau,Macao
5.School of Medicine,Guizhou University,Guizhou,China
6.Department of Medical Information Engineering,Sichuan University,Chengdu,610065,China
7.Department of Psychiatry,The Second Xiangya Hospital,Central South University,Changsha,410011,China
8.National Clinical Research Center on Mental Disorders,Changsha,410011,China
Recommended Citation
GB/T 7714
Lu,Fengmei,Wang,Mengyun,Xu,Shiyang,et al. Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder[J]. Brain Imaging and Behavior,2021,15(3):1201-1210.
APA Lu,Fengmei,Wang,Mengyun,Xu,Shiyang,Chen,Heng,Yuan,Zhen,Luo,Lizhu,Wang,Xiuli,Zhang,Jiang,Dai,Jing,Wang,Xiaoping,Chen,Huafu,&Zhou,Jiansong.(2021).Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder.Brain Imaging and Behavior,15(3),1201-1210.
MLA Lu,Fengmei,et al."Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder".Brain Imaging and Behavior 15.3(2021):1201-1210.
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