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Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging
Yuan,Zhen; Gao,Duyang
Conference NameSymposium on Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications, held at SPIE BiOS Conference
Source PublicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Conference DateFEB 02-03, 2020
Conference PlaceSan Francisco, CA

Controllable preparation of water-soluble multifunctional nanoprobes is of great significance for cancer early diagnosis. In this study, protein-modified hydrophilic copper sufide (CuS) nanotriangles with tunable absorption in the second near-infrared region are developed in the presence of halide ions. Further, DTPA-Gd3+ is conjugated on it by using the unique characteristics of the protein-protected nanotriangles. Specifically, the asobtained nanostructures are investigated as contrast agents for enhanced in vivo photoacoustic/magnetic resonance dual-modal tumor imaging. More importantly, in vitro and in vivo toxicity analysis are also performed, which show that the dual -modal nanoprobes are biocompatible for most of the cases. It is demonstrated that the novel asprepared protein-modified nanotriangles are able to work as a nanoplatform to construct dual-modal nanoprobes, which paves a new anenue for improving the photoacoustic/magnetic resonance imaging contrast in cancer detection. It should be pointed out that other functional blocks may also be linked on it, which makes it a general method to design multifunctional nanoprobes.

KeywordCus Nanotriangle Dual-modal Nanoprobe Magnetic Resonance Imaging Photoacoustic Imaging Protein-modified
URLView the original
Indexed ByCPCI-S
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Optics
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Optics
WOS IDWOS:000546254100008
Scopus ID2-s2.0-85082139842
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Document TypeConference paper
CollectionFaculty of Health Sciences
AffiliationFaculty of Health Sciences,University of Macau,Macao
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yuan,Zhen,Gao,Duyang. Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging[C],2020.
APA Yuan,Zhen,&Gao,Duyang.(2020).Protein-modified CuS nanotriangles for dual-modal photoacoustic and magnetic resonance imaging.Progress in Biomedical Optics and Imaging - Proceedings of SPIE,11254.
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