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Dual Role of Doxorubicin for Photopolymerization and Therapy
Zhang,Liwen1; Xie,Lisi2,3; Xu,Sihao1; Kuchel,Rhiannon P.4; Dai,Yunlu2,3; Jung,Kenward1; Boyer,Cyrille1
Source PublicationBiomacromolecules

In this study, we report dual roles for doxorubicin (DOX), which can serve as an antitumor drug as well as a cocatalyst for a photoliving radical polymerization. DOX enhances the polymerization rates of a broad range of monomers, including acrylamide, acrylate, and methacrylates, allowing for high monomer conversion and well-defined molecular weights under irradiation with a blue light-emitting diode light (λmax = 485 nm, 2.2 mW/cm2). Utilizing this property, the photopolymerization of N,N-diethylacrylamide was performed in the presence of a poly(oligo(ethylene glycol) methyl ether acrylate) macroreversible addition-fragmentation chain transfer (macroRAFT) agent to prepare polymeric nanoparticles via aqueous polymerization-induced self-assembly (PISA). By varying the monomer:macroRAFT ratio, spherical polymeric nanoparticles of various diameters could be produced. Most notably, DOX was successfully encapsulated into the hydrophobic core of nanoparticles during the PISA process. The DOX-loaded nanoparticles were effectively uptaken into tumor cells and significantly inhibited the proliferation of tumor cells, demonstrating that the DOX bioactivity was not affected by the polymerization reaction.

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Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000572822600037
Scopus ID2-s2.0-85090873951
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJung,Kenward
Affiliation1.Centre for Advanced Macromolecular Design,Australian Centre for NanoMedicine,School of Chemical Engineering,University of New South Wales,Sydney,2052,Australia
2.Cancer Centre,Faculty of Health Sciences,University of Macau,Macau, SAR,999078,Macao
3.Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau, SAR,999078,Macao
4.Electron Microscope Unit,Mark Wainwright Analytical Centre,University of New South Wales,Sydney,2052,Australia
Recommended Citation
GB/T 7714
Zhang,Liwen,Xie,Lisi,Xu,Sihao,et al. Dual Role of Doxorubicin for Photopolymerization and Therapy[J]. Biomacromolecules,2020,21(9):3887-3897.
APA Zhang,Liwen,Xie,Lisi,Xu,Sihao,Kuchel,Rhiannon P.,Dai,Yunlu,Jung,Kenward,&Boyer,Cyrille.(2020).Dual Role of Doxorubicin for Photopolymerization and Therapy.Biomacromolecules,21(9),3887-3897.
MLA Zhang,Liwen,et al."Dual Role of Doxorubicin for Photopolymerization and Therapy".Biomacromolecules 21.9(2020):3887-3897.
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