UM  > Institute of Chinese Medical Sciences
Affiliated with RCfalse
Status已發表Published
Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs
Xiong, Wei1; Xiong, Shi Hang1; Chen, Qi Ling1; Linghu, Ke Gang1; Zhao, Guan Ding1; Chu, John M.T.2; Wong, Gordon T.C.2; Li, Juan3; Hu, Yuan Jia1; Wang, Yi Tao1; Yu, Hua1,4
2021-08-15
Source PublicationCarbohydrate Polymers
ISSN0144-8617
Volume266
Abstract

The highly expressed P-glycoprotein (Pgp) in the intestine plays a key role in preventing drugs across the intestinal epithelium, which linked by tight junctions (TJs). Thus increasing the oral bioavailability of Pgp substrate-like drugs (PSLDs) remains a great challenge. Herein, we construct a nanocarrier system derived from Brij-grafted-chitosan (BC) to enhance the oral bioavailability and therapeutic effect of berberine (BBR, a typical PLSD) against diabetic kidney disease. The developed BC nanoparticles (BC-NPs) are demonstrated to improve the intestinal permeability of BBR via transiently and reversibly modulating the intercellular TJs (paracellular pathway) and Pgp-mediated drug efflux (transcellular pathway). As compared to free BBR and chitosan nanoparticles, the BC-NPs enhanced the relative oral bioavailability of BBR in rats (4.4- and 2.7-fold, respectively), and the therapeutic potency of BBR in renal function and histopathology. In summary, such strategy may provide an effective nanocarrier system for oral delivery of BBR and PSLDs.

KeywordBerberine Brij-grafted-chitosan Diabetic Kidney Disease Oral Nanocarrier P-glycoprotein
DOI10.1016/j.carbpol.2021.118112
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000655699800006
Scopus ID2-s2.0-85105014762
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYu, Hua
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao
2.Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
3.Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China
4.HKBU Shenzhen Research Center, Shenzhen, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xiong, Wei,Xiong, Shi Hang,Chen, Qi Ling,et al. Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs[J]. Carbohydrate Polymers,2021,266.
APA Xiong, Wei,Xiong, Shi Hang,Chen, Qi Ling,Linghu, Ke Gang,Zhao, Guan Ding,Chu, John M.T.,Wong, Gordon T.C.,Li, Juan,Hu, Yuan Jia,Wang, Yi Tao,&Yu, Hua.(2021).Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs.Carbohydrate Polymers,266.
MLA Xiong, Wei,et al."Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs".Carbohydrate Polymers 266(2021).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiong, Wei]'s Articles
[Xiong, Shi Hang]'s Articles
[Chen, Qi Ling]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiong, Wei]'s Articles
[Xiong, Shi Hang]'s Articles
[Chen, Qi Ling]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiong, Wei]'s Articles
[Xiong, Shi Hang]'s Articles
[Chen, Qi Ling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.