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Coptisine attenuates diabetes—associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress
Zhou, Yan; Zhou, Chunxiu; Zhang, Xutao; Vong, Chi Teng; Wang, Yitao; Cheang, Wai San
2021-07
Source PublicationMolecules
ISSN1420-3049
Volume26Issue:14
Abstract

Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Copti-sine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas and carotid arteries were obtained from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) and coptisine. Some arterial rings were obtained from diabetic mice, which were induced by high-fat diet (45% kcal% fat) feeding for 6 weeks combined with a low-dose intraperitoneal injection of streptozotocin (120 mg/kg). Functional studies showed that coptisine protected endothelium-dependent relaxation in aortas against risk factors and from diabetic mice. Coptisine increased phosphorylations of AMPK and eNOS and downregulated the endoplasmic reticulum (ER) stress markers as determined by Western blotting. Coptisine elevates NO bioavailabil-ity and decreases reactive oxygen species level. The results indicate that coptisine improves vascular function in diabetes through suppression of ER stress and oxidative stress, implying the therapeutic potential of coptisine to treat diabetic vasculopathy.

KeywordCoptisine Diabetes Endoplasmic Reticulum Stress Endothelial Dysfunction Oxidative Stress
DOI10.3390/molecules26144210
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000676602500001
Scopus ID2-s2.0-85111050790
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorCheang, Wai San
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhou, Yan,Zhou, Chunxiu,Zhang, Xutao,et al. Coptisine attenuates diabetes—associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress[J]. Molecules,2021,26(14).
APA Zhou, Yan,Zhou, Chunxiu,Zhang, Xutao,Vong, Chi Teng,Wang, Yitao,&Cheang, Wai San.(2021).Coptisine attenuates diabetes—associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress.Molecules,26(14).
MLA Zhou, Yan,et al."Coptisine attenuates diabetes—associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress".Molecules 26.14(2021).
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