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The potentials of uncariae ramulus cum uncis for the treatment of migraine: Targeting cgrp in the trigeminovascular system
Chong, Cheong Meng1; Zhong, Zhangfeng1; Vong, Chi Teng1; Wang, Shengpeng1; Lu, Jin Jian1; Zhong, Haijing2; Su, Huanxing1; Wang, Yitao1
2021-07-01
Source PublicationCurrent Neuropharmacology
ISSN1570-159X
Volume19Issue:7Pages:1090-1100
Abstract

Migraine is a common chronic neurovascular disease characterized by headaches. Calcitonin gene-related peptide (CGRP) signaling in the trigeminovascular system plays a critical role in the development of migraine. The monoclonal antibodies against CGRP and its receptor have been used clinically for the prevention of migraine; however, they may not be a cost-effective option for patients with low-frequency episodic migraine. Thus, it is quite valuable to search for an alternative strategy to downregulate CGRP signaling. Uncariae Ramulus Cum Uncis (UR) has a longterm history for the treatment of cardiovascular and central nervous systems disorders in China and Eastern Asia. Several clinical studies showed that famous herbal formulas comprising UR were able to improve headaches in migraineurs. In addition, increasing in vivo studies further indicated that migraine-related changes, such as CGRP increase, inflammation, nitric oxide increase, and spontaneous behavior problems could be reduced by UR extraction and its active constituents. In this review, we summarize the pathophysiological factors affecting abnormal CGRP release in the trigeminovascular system during a migraine, and for the first time, analyze the effects of UR on these factors and evaluate the potentials of UR for the treatment of migraine.

KeywordCgrp Inflammation Migraine Nitric Oxide Trigeminovascular System Uncariae Ramulus Cum Uncis
DOI10.2174/1570159X18666201029150937
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000684566900004
Scopus ID2-s2.0-85112124495
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChong, Cheong Meng; Wang, Yitao
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou, 510632, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chong, Cheong Meng,Zhong, Zhangfeng,Vong, Chi Teng,et al. The potentials of uncariae ramulus cum uncis for the treatment of migraine: Targeting cgrp in the trigeminovascular system[J]. Current Neuropharmacology,2021,19(7):1090-1100.
APA Chong, Cheong Meng,Zhong, Zhangfeng,Vong, Chi Teng,Wang, Shengpeng,Lu, Jin Jian,Zhong, Haijing,Su, Huanxing,&Wang, Yitao.(2021).The potentials of uncariae ramulus cum uncis for the treatment of migraine: Targeting cgrp in the trigeminovascular system.Current Neuropharmacology,19(7),1090-1100.
MLA Chong, Cheong Meng,et al."The potentials of uncariae ramulus cum uncis for the treatment of migraine: Targeting cgrp in the trigeminovascular system".Current Neuropharmacology 19.7(2021):1090-1100.
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