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Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems
Chen, Zhejie1,2; Farag, Mohamed A.3,4; Zhong, Zhangfeng2; Zhang, Chen5; Yang, Yu6; Wang, Shengpeng1; Wang, Yitao1
2021-09
Source PublicationAdvanced Drug Delivery Reviews
ISSN0169-409X
Volume176Pages:113870
Abstract

As naturally occurring bioactive products, several lines of evidence have shown the potential of polyphenols in the medical intervention of various diseases, including tumors, inflammatory diseases, and cardiovascular diseases. Notably, owing to the particular molecular structure, polyphenols can combine with proteins, metal ions, polymers, and nucleic acids providing better strategies for polyphenol-delivery strategies. This contributes to the inherent advantages of polyphenols as important functional components for other drug delivery strategies, e.g., protecting nanodrugs from oxidation as a protective layer, improving the physicochemical properties of carbohydrate polymer carriers, or being used to synthesize innovative functional delivery vehicles. Polyphenols have emerged as a multifaceted player in novel drug delivery systems, both as therapeutic agents delivered to intervene in disease progression and as essential components of drug carriers. Although an increasing number of studies have focused on polyphenol-based nanodrug delivery including epigallocatechin-3-gallate, curcumin, resveratrol, tannic acid, and polyphenol-related innovative preparations, these molecules are not without inherent shortcomings. The active biochemical characteristics of polyphenols constitute a prerequisite to their high-frequency use in drug delivery systems and likewise to provoke new challenges for the design and development of novel polyphenol drug delivery systems of improved efficacies. In this review, we focus on both the targeted delivery of polyphenols and the application of polyphenols as components of drug delivery carriers, and comprehensively elaborate on the application of polyphenols in new types of drug delivery systems. According to the different roles played by polyphenols in innovative drug delivery strategies, potential limitations and risks are discussed in detail including the influences on the physical and chemical properties of nanodrug delivery systems, and their influence on normal physiological functions inside the organism.

KeywordCoordination Bonded Hydrogen Bonded Metal-phenolic Networks Nanodrug Delivery Polyphenols Supramolecular Design
DOI10.1016/j.addr.2021.113870
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000697164900012
Scopus ID2-s2.0-85111073140
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Shengpeng; Wang, Yitao
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2.Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
4.Chemistry Department, American University in Cairo AUC, Cairo, Egypt
5.College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
6.Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen, Zhejie,Farag, Mohamed A.,Zhong, Zhangfeng,et al. Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems[J]. Advanced Drug Delivery Reviews,2021,176:113870.
APA Chen, Zhejie,Farag, Mohamed A.,Zhong, Zhangfeng,Zhang, Chen,Yang, Yu,Wang, Shengpeng,&Wang, Yitao.(2021).Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems.Advanced Drug Delivery Reviews,176,113870.
MLA Chen, Zhejie,et al."Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems".Advanced Drug Delivery Reviews 176(2021):113870.
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