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Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway
Luo, Hua1,2,5; Hao, Erwei1,2; Tan, Dechao1,2; Wei, Wei1,2; Xie, Jinling1,2; Feng, Xiaohui1,2; Du, Zhengcai1,2; Huang, Chunying1,2; Bai, Gang4; Hou, Yuanyuan4; Cheng, Chuanjing4; Yi, Xiangxi1,2; Wang, Yitao5; Hou, Xiaotao1,2,3; Deng, Jiagang1,2
2019-12-01
Source PublicationFood and Chemical Toxicology
ISSN0278-6915
Volume134
Abstract

Aegiceras corniculatum (L.) Blanco is known to exhibit anticancer effects against different types of cancer; however, to the best of our knowledge, the anticancer activity and underlying mechanisms of action of A. corniculatum leaf extract on colorectal cancer have not been elucidated. In the present study, colony-forming assay, western blot analysis, flow cytometry, and a xenograft model were used to investigate the effects of an n-butanol extract of A. corniculatum leaves (NACL) on colorectal cancer in vitro and in vivo. The results showed that NACL inhibits the viability and proliferation of colorectal cancer cells in a dose-dependent manner. Besides, NACL also induces cell apoptosis and cell cycle arrest by activating Forkhead box proteins and controlling the cell cycle checkpoint pathways, which are associated with the caspase-dependent mitochondrial apoptotic cascades and Bcl-2 family proteins. More importantly, the tumour sizes in HT-29 xenograft nude mice decreased after treatment with NACL in vivo. These findings indicate that A. corniculatum leaf extracts have potent anticancer activities across different colorectal and other solid tumour cell lines, via regulation of the cell cycle and apoptosis; thus, it has the potential to be developed as an anticancer agent to enhance clinical standards of care for patients with colorectal cancer.

KeywordAegiceras Corniculatum Apoptosis Cell Cycle Colorectal Cancer Forkhead Box
DOI10.1016/j.fct.2019.110861
URLView the original
Indexed BySCIE ; CPCI-S
Language英語English
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000496839500024
Scopus ID2-s2.0-85073027408
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLuo, Hua; Hao, Erwei; Hou, Xiaotao; Deng, Jiagang
Affiliation1.Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning, China
2.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine, Nanning, China
3.Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China
4.College of Pharmacy, Nankai University, Tianjing, China
5.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Luo, Hua,Hao, Erwei,Tan, Dechao,et al. Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway[J]. Food and Chemical Toxicology,2019,134.
APA Luo, Hua,Hao, Erwei,Tan, Dechao,Wei, Wei,Xie, Jinling,Feng, Xiaohui,Du, Zhengcai,Huang, Chunying,Bai, Gang,Hou, Yuanyuan,Cheng, Chuanjing,Yi, Xiangxi,Wang, Yitao,Hou, Xiaotao,&Deng, Jiagang.(2019).Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway.Food and Chemical Toxicology,134.
MLA Luo, Hua,et al."Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway".Food and Chemical Toxicology 134(2019).
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