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Mito-Bomb: Targeting Mitochondria for Cancer Therapy
Guo, Xiaolu1; Yang, Naidi1; Ji, Wenhui1; Zhang, Hang1; Dong, Xiao2; Zhou, Zhiqiang1; Li, Lin1; Shen, Han Ming3; Yao, Shao Q.2; Huang, Wei1,4
Source PublicationAdvanced Materials

Cancer has been one of the most common life-threatening diseases for a long time. Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) have limited effects due to drug resistance, unsatisfactory treatment efficiency, and side effects. In recent years, photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) have been utilized for cancer treatment owing to their high selectivity, minor resistance, and minimal toxicity. Accumulating evidence has demonstrated that selective delivery of drugs to specific subcellular organelles can significantly enhance the efficiency of cancer therapy. Mitochondria-targeting therapeutic strategies are promising for cancer therapy, which is attributed to the essential role of mitochondria in the regulation of cancer cell apoptosis, metabolism, and more vulnerable to hyperthermia and oxidative damage. Herein, the rational design, functionalization, and applications of diverse mitochondria-targeting units, involving organic phosphine/sulfur salts, quaternary ammonium (QA) salts, peptides, transition-metal complexes, guanidinium or bisguanidinium, as well as mitochondria-targeting cancer therapies including PDT, PTT, CDT, and others are summarized. This review aims to furnish researchers with deep insights and hints in the design and applications of novel mitochondria-targeting agents for cancer therapy.

KeywordCancer Therapy Chemodynamic Therapy Mitochondria Photodynamic Therapy Photothermal Therapy
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000695022400001
Scopus ID2-s2.0-85114706011
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Cited Times [WOS]:65   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLi, Lin; Yao, Shao Q.; Huang, Wei
Affiliation1.Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 30 South Puzhu Road, 211800, China
2.Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore
3.Faculty of Health Sciences, University of Macau, China
4.Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, 127 West Youyi Road, 710072, China
Recommended Citation
GB/T 7714
Guo, Xiaolu,Yang, Naidi,Ji, Wenhui,et al. Mito-Bomb: Targeting Mitochondria for Cancer Therapy[J]. Advanced Materials,2021,33(43).
APA Guo, Xiaolu,Yang, Naidi,Ji, Wenhui,Zhang, Hang,Dong, Xiao,Zhou, Zhiqiang,Li, Lin,Shen, Han Ming,Yao, Shao Q.,&Huang, Wei.(2021).Mito-Bomb: Targeting Mitochondria for Cancer Therapy.Advanced Materials,33(43).
MLA Guo, Xiaolu,et al."Mito-Bomb: Targeting Mitochondria for Cancer Therapy".Advanced Materials 33.43(2021).
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