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Targeting Aggrephagy for the Treatment of Alzheimer's Disease
Malampati, Sandeep1; Song, Ju Xian1,2; Chun-Kit Tong, Benjamin1; Nalluri, Anusha1; Yang, Chuan Bin1; Wang, Ziying1; Gopalkrishnashetty Sreenivasmurthy, Sravan1; Zhu, Zhou1; Liu, Jia1; Su, Chengfu1; Krishnamoorthi, Senthilkumar1; Iyaswamy, Ashok1; Cheung, King Ho1; Lu, Jia Hong3; Li, And Min1
2020-01-28
Source PublicationCells
Volume9Issue:2
Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggregates in the brain, causing progressive dementia. Increasing studies have provided evidence that the defect in protein-degrading systems, especially the autophagy-lysosome pathway (ALP), plays an important role in the pathogenesis of AD. Recent studies have demonstrated that AD-associated protein aggregates can be selectively recognized by some receptors and then be degraded by ALP, a process termed aggrephagy. In this study, we reviewed the role of aggrephagy in AD development and discussed the strategy of promoting aggrephagy using small molecules for the treatment of AD.

KeywordAggregates Aggrephagy Alzheimer’s Disease Selective Autophagy
DOI10.3390/cells9020311
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000521944900052
Scopus ID2-s2.0-85089725259
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research, China
2.Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China
Recommended Citation
GB/T 7714
Malampati, Sandeep,Song, Ju Xian,Chun-Kit Tong, Benjamin,et al. Targeting Aggrephagy for the Treatment of Alzheimer's Disease[J]. Cells,2020,9(2).
APA Malampati, Sandeep,Song, Ju Xian,Chun-Kit Tong, Benjamin,Nalluri, Anusha,Yang, Chuan Bin,Wang, Ziying,Gopalkrishnashetty Sreenivasmurthy, Sravan,Zhu, Zhou,Liu, Jia,Su, Chengfu,Krishnamoorthi, Senthilkumar,Iyaswamy, Ashok,Cheung, King Ho,Lu, Jia Hong,&Li, And Min.(2020).Targeting Aggrephagy for the Treatment of Alzheimer's Disease.Cells,9(2).
MLA Malampati, Sandeep,et al."Targeting Aggrephagy for the Treatment of Alzheimer's Disease".Cells 9.2(2020).
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