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Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging
Wu, Yayun1,2; Chen, Zhizhen3; Zhang, Pengfei1,4; Zhou, Lihua1; Jiang, Tao1; Chen, Huajie5,6; Gong, Ping1; Dimitrov, Dimiter S.7; Cai, Lintao1; Zhao, Qi3
2018-07-07
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume54Issue:53Pages:7314-7317
Abstract

We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.

DOI10.1039/c8cc03037e
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000436566700009
PublisherROYAL SOC CHEMISTRY
The Source to ArticleWOS
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorZhao, Qi
Affiliation1.Chinese Acad Sci, Shenzhen Engn Lab Nanomed & Nanoformulat, CAS Key Lab Hlth Informat,Guangdong Key Lab Nanom, Shenzhen Inst Adv Technol,Inst Biomed & Biotechno, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Research Educ Ctr Excellence Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China
3.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Hong Kong, Peoples R China
5.Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Adv Funct Polymer Mat,Coll Hunan Prov, Xiangtan 411105, Peoples R China
6.Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environmentally Friendly Chem & Applicat, Xiangtan 411105, Peoples R China
7.Univ Pittsburgh, Med Sch, Ctr Antibody Therapeut, Pittsburgh, PA USA
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Wu, Yayun,Chen, Zhizhen,Zhang, Pengfei,et al. Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging[J]. CHEMICAL COMMUNICATIONS,2018,54(53):7314-7317.
APA Wu, Yayun,Chen, Zhizhen,Zhang, Pengfei,Zhou, Lihua,Jiang, Tao,Chen, Huajie,Gong, Ping,Dimitrov, Dimiter S.,Cai, Lintao,&Zhao, Qi.(2018).Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging.CHEMICAL COMMUNICATIONS,54(53),7314-7317.
MLA Wu, Yayun,et al."Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging".CHEMICAL COMMUNICATIONS 54.53(2018):7314-7317.
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