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Sex-Specific Associations of MIR137 Polymorphisms With Schizophrenia in a Han Chinese Cohort
Yin, Jingwen1,2,3,5; Luo, Xudong1; Peng, Qian1; Xiong, Susu1; Lv, Dong1; Dai, Zhun1; Fu, Jiawu6; Wang, Ying1; Wei, Yaxue1; Liang, Chunmei6; Xu, Xusan6; Zhang, Dandan1; Wang, Lulu1; Zhu, Dongjian1; Wen, Xia6; Ye, Xiaoqing1; Lin, Zhixiong1; Lin, Juda1; Li, You6; Wang, Jiafeng4; Ma, Guoda6,7; Li, Keshen6,7; Wang, Yajun7
2021-02-23
Source PublicationFrontiers in Genetics
ISSN1664-8021
Volume12
Abstract

Objective: To investigate the effects of microRNA-137 (MIR137) polymorphisms (rs1198588 and rs2660304) on the risk of schizophrenia in a Han Chinese population.

Methods: Schizophrenia was diagnosed according to the DSM-5. Clinical symptoms and cognitive functions were assessed with the Positive and Negative Symptom Scale (PANSS) and Brief Assessment of Cognition in Schizophrenia (BACS), respectively. The polymorphisms were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 1,116 patients with schizophrenia and 1,039 healthy controls.

Results: Significant associations were found between schizophrenia and MIR137 in the distributions of genotypes (p = 0.037 for rs1198588; p = 0.037 for rs2660304, FDR corrected) and alleles (p = 0.043 for rs1198588; p = 0.043 for rs2660304, FDR corrected) of two SNPs. When the population was stratified by sex, we found female-specific associations between MIR137 and schizophrenia in terms of genotype and allele distributions of rs1198588 (chi(2) = 4.41, p = 0.036 and chi(2) = 4.86, p = 0.029, respectively, FDR corrected) and rs2660304 (chi(2) = 4.74, p=0.036 and chi(2) = 4.80, p = 0.029, respectively, FDR corrected). Analysis of the MIR137 haplotype rs1198588-rs2660304 showed a significant association with schizophrenia in haplotype T-T [chi(2) = 4.60, p = 0.032, OR = 1.32, 95% CI (1.02-1.70)]. Then, significant female-specific associations were found with the haplotypes T-T and G-A [chi(2) = 4.92, p = 0.027, OR = 1.62, 95% CI (1.05-2.50); chi(2) = 4.42, p = 0.035, OR = 0.62, 95% CI (0.39-0.97), respectively]. When the TT genotype of rs1198588 was compared to the GT+GG genotype, a clinical characteristics analysis also showed a female-specific association in category instances (t = 2.76, p = 0.042, FDR corrected).

Conclusion: The polymorphisms within the MIR137 gene are associated with susceptibility to schizophrenia, and a female-specific association of MIR137 with schizophrenia was reported in a Han Chinese population.

KeywordMir137 Polymorphism Rs1198588 Rs2660304 Schizophrenia
DOI10.3389/fgene.2021.627874
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000626633300001
Scopus ID2-s2.0-85102349831
Fulltext Access
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorMa, Guoda; Li, Keshen; Wang, Yajun
Affiliation1.Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
2.Center for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of Macau, Taipa, Macao
3.Department of Psychology, Faculty of Social Sciences, University of Macau, Taipa, Macao
4.Maternal and Children’s Health Research Institute, Shunde Maternal and Children’s Hospital, Guangdong Medical University, Foshan, China
5.Institute of Neurology, Guangdong Medical University, Zhanjiang, China
6.Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
7.Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
First Author AffilicationINSTITUTE OF COLLABORATIVE INNOVATION;  Faculty of Social Sciences
Recommended Citation
GB/T 7714
Yin, Jingwen,Luo, Xudong,Peng, Qian,et al. Sex-Specific Associations of MIR137 Polymorphisms With Schizophrenia in a Han Chinese Cohort[J]. Frontiers in Genetics,2021,12.
APA Yin, Jingwen.,Luo, Xudong.,Peng, Qian.,Xiong, Susu.,Lv, Dong.,Dai, Zhun.,Fu, Jiawu.,Wang, Ying.,Wei, Yaxue.,Liang, Chunmei.,Xu, Xusan.,Zhang, Dandan.,Wang, Lulu.,Zhu, Dongjian.,Wen, Xia.,Ye, Xiaoqing.,Lin, Zhixiong.,Lin, Juda.,Li, You.,...&Wang, Yajun.(2021).Sex-Specific Associations of MIR137 Polymorphisms With Schizophrenia in a Han Chinese Cohort.Frontiers in Genetics,12.
MLA Yin, Jingwen,et al."Sex-Specific Associations of MIR137 Polymorphisms With Schizophrenia in a Han Chinese Cohort".Frontiers in Genetics 12(2021).
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