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Brain structure, cardiorespiratory fitness, and executive control changes after a 9-week exercise intervention in young adults: A randomized controlled trial
Zhu,Lina1; Yu,Qian2; Herold,Fabian3; Cheval,Boris4,5; Dong,Xiaoxiao6; Cui,Lei1; Xiong,Xuan6; Chen,Aiguo6; Yin,Hengchan1; Kong,Zhaowei7; Mueller,Notger3; Kramer,Arthur F.8,9; Zou,Liye2
2021-04-01
Source PublicationLife-Basel
ISSN2075-1729
Volume11Issue:4
Abstract

Cardiorespiratory fitness (CRF) is assumed to exert beneficial effects on brain structure and executive control (EC) performance. However, empirical evidence of exercise-induced cognitive enhancement is not conclusive, and the role of CRF in younger adults is not fully understood. Here, we conducted a study in which healthy young adults took part in a moderate aerobic exercise intervention program for 9 weeks (exercise group; n = 48), or control condition of non-aerobic exercise intervention (waitlist control group; n = 72). Before and after the intervention period maximal oxygen uptake (VO2max) as an indicator of CRF, the Flanker task as a measure of EC performance and grey matter volume (GMV), as well as cortical thickness via structural magnetic resonance imaging (MRI), were assessed. Compared to the control group, the CRF (heart rate, p < 0.001; VO2max, p < 0.001) and EC performance (congruent and incongruent reaction time, p = 0.011, p < 0.001) of the exercise group were significantly improved after the 9-week aerobic exercise intervention. Furthermore, GMV changes in the left medial frontal gyrus increased in the exercise group, whereas they were significantly reduced in the control group. Likewise, analysis of cortical morphology revealed that the left lateral occipital cortex (LOC.L) and the left precuneus (PCUN.L) thickness were considerably increased in the exercise group, which was not observed in the control group. The exploration analysis confirmed that CRF improvements are linked to EC improvement and frontal grey matter changes. In summary, our results support the idea that regular endurance exercises are an important determinant for brain health and cognitive performance even in a cohort of younger adults.

KeywordAerobic Fitness Cortical Thickness Executive Control Exercise Intervention Grey Matter Randomized Controlled Trial
DOI10.3390/life11040292
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaLife Sciences & Biomedicine - Other Topics ; Microbiology
WOS SubjectBiology ; Microbiology
WOS IDWOS:000643236500001
Scopus ID2-s2.0-85103541696
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Education
Corresponding AuthorYin,Hengchan; Zou,Liye
Affiliation1.School of Physical Education and Sports Science, Beijing Normal University, Beijing, 100875, China
2.Institute of Collaborative Innovation (Sport-Psychology-Education), School of Psychology, Shenzhen University, Shenzhen, 518060, China
3.German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120, Germany
4.Swiss Center for Affective Sciences, University of Geneva, Geneva, 1205, Switzerland
5.Department of Psychology, FPSE, University of Geneva, Geneva, 1205, Switzerland
6.College of Physical Education, Yangzhou University, Yangzhou, 225127, China
7.Faculty of Education, University of Macau, Macao, China
8.Center for Cognitive and Brain Health, Department of Psychology, Northeastern University, Boston, 02115, United States
9.Beckman Institute, University of Illinois at Urbana-Champaign, Champaign, 61801, United States
Corresponding Author AffilicationINSTITUTE OF COLLABORATIVE INNOVATION
Recommended Citation
GB/T 7714
Zhu,Lina,Yu,Qian,Herold,Fabian,et al. Brain structure, cardiorespiratory fitness, and executive control changes after a 9-week exercise intervention in young adults: A randomized controlled trial[J]. Life-Basel,2021,11(4).
APA Zhu,Lina,Yu,Qian,Herold,Fabian,Cheval,Boris,Dong,Xiaoxiao,Cui,Lei,Xiong,Xuan,Chen,Aiguo,Yin,Hengchan,Kong,Zhaowei,Mueller,Notger,Kramer,Arthur F.,&Zou,Liye.(2021).Brain structure, cardiorespiratory fitness, and executive control changes after a 9-week exercise intervention in young adults: A randomized controlled trial.Life-Basel,11(4).
MLA Zhu,Lina,et al."Brain structure, cardiorespiratory fitness, and executive control changes after a 9-week exercise intervention in young adults: A randomized controlled trial".Life-Basel 11.4(2021).
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