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Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer
Yue, Ludan1; Sun, Tianlei1,2; Yang, Kuikun1; Cheng, Qian1; Li, Junyan1; Pan, Yue3; Wang, Shu2; Wang, Ruibing1
2021-06-07
Source PublicationNanoscale
ISSN2040-3364
Volume13Issue:21Pages:9570-9576
Abstract

Glucose starvation has emerged as a therapeutic strategy to inhibit tumor growth by regulating glucose metabolism. However, the rapid proliferation of cancer cells could induce the hypoxic tumor microenvironment (TME) which limits the therapeutic efficacy of glucose starvation by vascular isomerization. Herein, we developed a "dual-lock"supramolecular nanomedicine system for synergistic cancer therapy by integrating glucose oxidase (GOx) induced starvation and hypoxia-activated gene therapy. The host-guest interactions (that mediate nano-assembly formation) and hypoxia-activatable promoters act as two locks to keep glucose oxidase (GOx) and a therapeutic plasmid (RTP801::p53) inside supramolecular gold nanovesicles (Au NVs). Upon initial dissociation of the host-guest interactions and hence Au NVs by cancer-specific reactive oxygen species (ROS), GOx is released to consume glucose and oxygen, generate H2O2 and induce the hypoxic TME, which act as the two keys for triggering burst payload release and promoter activation, thus allowing synergistic starvation and gene therapy of cancer. This "dual-lock"supramolecular nanomedicine exhibited integrated therapeutic effects in vitro and in vivo for tumor suppression.

DOI10.1039/d1nr02159a
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000651772200001
Scopus ID2-s2.0-85107606943
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Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorWang, Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
2.Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
3.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yue, Ludan,Sun, Tianlei,Yang, Kuikun,et al. Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer[J]. Nanoscale,2021,13(21):9570-9576.
APA Yue, Ludan,Sun, Tianlei,Yang, Kuikun,Cheng, Qian,Li, Junyan,Pan, Yue,Wang, Shu,&Wang, Ruibing.(2021).Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer.Nanoscale,13(21),9570-9576.
MLA Yue, Ludan,et al."Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer".Nanoscale 13.21(2021):9570-9576.
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