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Multi-functionalized dendrimers for targeted co-delivery of sorafenib and paclitaxel in liver cancers
Ma, Guanglan1; Du, Xiao2; Zhu, Jianping1; Xu, Feng1; Yu, Hua3; Li, Juan1
2021-06-01
Source PublicationJournal of Drug Delivery Science and Technology
ISSN1773-2247
Volume63
Abstract

Liver cancer is one of the leading causes of cancer mortality worldwide. In this study, poly(lactide) (PLA) and hyaluronic acid (HA) co-modified half-generation of PAMAM G4.5 dendrimers (sPA) was chosen as the intelligent carrier for co-delivery of paclitaxel (PTX) and sorafenib (SOR) to treat liver cancer. The multifunctional micelle (HA-PALA@PTX + SOR) possessed a uniform size of 152.6 nm, good stability against serum medium, and a rapid in vitro drug release behavior under acidic condition in the presence of HAase. Cellular uptake study demonstrated an efficient intracellular delivery and drug accumulation in HepG2 cells. The antitumor and anti-metastasis efficacy of functionalized micelle was more obvious than that of free drugs. These data provided strong evidence that HA-PALA@PTX + SOR micelle could be utilized as a biocompatible and tumor targeted nano-carrier for the delivery of multiple anticancer drugs in liver cancer treatment.

KeywordCombination Chemotherapy Liver Cancer Metastasis Micelles Nanomedicine
DOI10.1016/j.jddst.2021.102493
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000670350500004
Scopus ID2-s2.0-85105006785
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLi, Juan
Affiliation1.Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, China
2.Division of Clinical Pharmacy, Department of Pharmacy, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, 210000, China
3.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, China
Recommended Citation
GB/T 7714
Ma, Guanglan,Du, Xiao,Zhu, Jianping,et al. Multi-functionalized dendrimers for targeted co-delivery of sorafenib and paclitaxel in liver cancers[J]. Journal of Drug Delivery Science and Technology,2021,63.
APA Ma, Guanglan,Du, Xiao,Zhu, Jianping,Xu, Feng,Yu, Hua,&Li, Juan.(2021).Multi-functionalized dendrimers for targeted co-delivery of sorafenib and paclitaxel in liver cancers.Journal of Drug Delivery Science and Technology,63.
MLA Ma, Guanglan,et al."Multi-functionalized dendrimers for targeted co-delivery of sorafenib and paclitaxel in liver cancers".Journal of Drug Delivery Science and Technology 63(2021).
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