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Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression
Bao, Wanrong1; Zhang, Quanwei1; Zheng, Hongming1; Li, Lifeng1; Liu, Man1; Cheng, Huiyuan1; Wong, Tinlong1; Zhang, Ge1; Lu, Aiping1; Bian, Zhaoxiang1; Ma, Diklung2; Leung, Chunghang3; Han, Quanbin1
2021-07-31
Source PublicationInternational Journal of Biological Macromolecules
ISSN0141-8130
Volume183Pages:1715-1722
Abstract

Radix Astragali polysaccharide RAP has been reported to play a crucial role in hematopoiesis without a clear mechanism. In this study, RAP's effects to enhance the recovery of cyclophosphamide (Cy)-suppressed bone marrow and blood cells is confirmed in vivo first. Confocal micrographs demonstrated the interesting direct binding of FITC-RAP to hematopoietic stem cells (HSC) in bone marrow. RAP protects both mice and human HSC in terms of cell morphology, proliferation, and apoptosis. RNA-sequencing and shRNA approaches revealed FOS to be a key regulator in RAP's protection. These evidences provide an unreported mechanism that RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression.

KeywordAstragalus Polysaccharide Fos Hematopoietic Stem Cell Myelosuppression Protective Effect
DOI10.1016/j.ijbiomac.2021.05.120
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000675833200010
Scopus ID2-s2.0-85106907787
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorMa, Diklung; Leung, Chunghang; Han, Quanbin
Affiliation1.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, 999077, Hong Kong
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, 999077, Hong Kong
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bao, Wanrong,Zhang, Quanwei,Zheng, Hongming,et al. Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression[J]. International Journal of Biological Macromolecules,2021,183:1715-1722.
APA Bao, Wanrong,Zhang, Quanwei,Zheng, Hongming,Li, Lifeng,Liu, Man,Cheng, Huiyuan,Wong, Tinlong,Zhang, Ge,Lu, Aiping,Bian, Zhaoxiang,Ma, Diklung,Leung, Chunghang,&Han, Quanbin.(2021).Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression.International Journal of Biological Macromolecules,183,1715-1722.
MLA Bao, Wanrong,et al."Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression".International Journal of Biological Macromolecules 183(2021):1715-1722.
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