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Conjugated Polymer-Ferrocence Nanoparticle as an NIR-II Light Powered Nanoamplifier to Enhance Chemodynamic Therapy
He, Yuling1; Jin, Xinyu1; Guo, Shuwen3; Zhao, Hongxia1; Liu, Ying1,2; Ju, Huangxian1
2021-07-14
Source PublicationACS Applied Materials and Interfaces
ISSN1944-8244
Volume13Issue:27Pages:31452-31461
Abstract

Chemodynamic therapy (CDT) is a promising therapeutic modality with transition metal ions and endogenous H2O2 as reagents, but its efficiency is impaired by low endogenous H2O2 levels and nonregeneration of metal ions. Most intracellular H2O2 supplement strategies use oxidases and are intensively dependent on oxygen participation. The hypoxia microenvironments of solid tumors weaken their performance. Here, we develop a near-infrared II light powered nanoamplifier to improve the local oxygen level and to enhance CDT. The nanoamplifier CPNP-Fc/Pt consists of ferrocene (Fc)- and cisplatin prodrug (Pt(IV))-modified conjugated polymer nanoparticles (CPNPs). CPNP has a donor-acceptor structure and demonstrates a good photothermal effect under 1064 nm light irradiation, which accelerates blood flow and efficiently elevates the local oxygen content. In response to intracellular glutathione, Pt(II) is released from CPNP-Fc/Pt and triggers enzymatic cascade reactions with nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) and superoxide dismutase to convert oxygen into H2O2. The enhanced oxygen level results in efficient intracellular H2O2 supply. Fc is reacted with H2O2 and converted to Fc+ via the Fenton reaction, with the generation of hydroxyl radicals for CDT. Unlike free metal ions, the Fe(III) in Fc+ is reduced to Fe(II) by intracellular NAD(P)H, which achieves the regeneration of Fc. The sufficient intracellular H2O2 supply and efficient Fc regeneration effectively enhance the Fenton reaction and demonstrate good in vivo CDT results with tumor growth suppression. This design offers a promising strategy to enhance CDT efficiency in the hypoxia microenvironment of solid tumors.

KeywordChemodynamic Therapy (Cdt) H2o2supplement Nanoamplifier Nir-ii Light Tumor Therapy
DOI10.1021/acsami.1c06613
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000674333400012
Scopus ID2-s2.0-85110976298
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLiu, Ying
Affiliation1.State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China
2.Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing, 210023, China
3.State Key Laboratory of Quality Research in Chinese Medic, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
Recommended Citation
GB/T 7714
He, Yuling,Jin, Xinyu,Guo, Shuwen,et al. Conjugated Polymer-Ferrocence Nanoparticle as an NIR-II Light Powered Nanoamplifier to Enhance Chemodynamic Therapy[J]. ACS Applied Materials and Interfaces,2021,13(27):31452-31461.
APA He, Yuling,Jin, Xinyu,Guo, Shuwen,Zhao, Hongxia,Liu, Ying,&Ju, Huangxian.(2021).Conjugated Polymer-Ferrocence Nanoparticle as an NIR-II Light Powered Nanoamplifier to Enhance Chemodynamic Therapy.ACS Applied Materials and Interfaces,13(27),31452-31461.
MLA He, Yuling,et al."Conjugated Polymer-Ferrocence Nanoparticle as an NIR-II Light Powered Nanoamplifier to Enhance Chemodynamic Therapy".ACS Applied Materials and Interfaces 13.27(2021):31452-31461.
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