UM  > Institute of Chinese Medical Sciences
Affiliated with RCfalse
Status已發表Published
Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease
Li, Tianzhong1,2; Liu, Yao3; Bao, Wenli1; Luo, Jingshan3; Gao, Lingfeng1; Chen, Xiaojia4; Wang, Shengpeng4; Yu, Jiangtian2; Ge, Yanqi1; Zhang, Bin1; Xie, Ni1; Xie, Zhongjian2; Chen, Tongkai3; Zhang, Han1
2021-07-01
Source PublicationAdvanced Therapeutics
ISSN2366-3987
Volume4Issue:7Pages:2100082
Abstract

Successful treatment of Parkinson's disease (PD) is impeded by limited permeability of the blood brain barrier (BBB) which causes unsatisfactory drug accumulation in the central nervous system (CNS). In the present study, a novel 2D graphdiyne (GDY)-based nanoplatform is utilized for the delivery of minocycline (MN), one drug candidate for PD treatment. These GDY nanosheets are prepared by sonication and exhibit excellent photothermal (PT) conversion ability (≈32%) without obvious toxicity in vitro. MN can be loaded onto GDY by π–π stacking (≈90%) and near infrared (NIR) irradiation is able to trigger the release of more than 30% of the payload. The BBB permeability of GDY is confirmed in both cellular and animal models. The behavioral defects of PD mice can be corrected after the PT and chemical synergistic treatment performed by GDY, with the dopaminergic neuron counting restored to normal level. Nanosheets-mediated PT treatment exhibits comparable therapeutic effects to that of L-DOPA, a commercialized PD drug. No obvious damage to major organs or circulation system is detected and physiological parameters remain stable during the behavioral study. This GDY-based delivery system can serve as a promising platform for loading chemical drugs targeting neurodegenerative disorders.

KeywordDrug Delivery Graphdiyne Minocycline Parkinson's Disease Photothermal Therapy
DOI10.1002/adtp.202100082
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000652520200001
Scopus ID2-s2.0-85105986027
Fulltext Access
Citation statistics
Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXie, Zhongjian; Chen, Tongkai; Zhang, Han
Affiliation1.Shenzhen Univ, Shenzhen Peoples Hosp 2,Minist Educ,Dept & Bioban, Hlth Sci Ctr,Int Collaborat Lab 2D Mat Optoelect, Inst Microscale Optoelect,Coll Phys & Optoelect E, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
2.Shenzhen International Institute for Biomedical Research, Shenzhen, 3/F, Building 1-B, Silver Star Hi-tech Industrial Park, Longhua District, 518110, China
3.Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, No. 12, Airport Road, Baiyun District, 510405, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, 999078, Macao
Recommended Citation
GB/T 7714
Li, Tianzhong,Liu, Yao,Bao, Wenli,et al. Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease[J]. Advanced Therapeutics,2021,4(7):2100082.
APA Li, Tianzhong,Liu, Yao,Bao, Wenli,Luo, Jingshan,Gao, Lingfeng,Chen, Xiaojia,Wang, Shengpeng,Yu, Jiangtian,Ge, Yanqi,Zhang, Bin,Xie, Ni,Xie, Zhongjian,Chen, Tongkai,&Zhang, Han.(2021).Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease.Advanced Therapeutics,4(7),2100082.
MLA Li, Tianzhong,et al."Synergistic Photothermal and Chemical Therapy by Smart Dual-Functional Graphdiyne Nanosheets for Treatment of Parkinson's Disease".Advanced Therapeutics 4.7(2021):2100082.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Tianzhong]'s Articles
[Liu, Yao]'s Articles
[Bao, Wenli]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Tianzhong]'s Articles
[Liu, Yao]'s Articles
[Bao, Wenli]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Tianzhong]'s Articles
[Liu, Yao]'s Articles
[Bao, Wenli]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.