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Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy
Enkhbat, Myagmartsend1,2; Liu, Yung Chiang1; Kim, Jua1; Xu, Yanshan1; Yin, Zongyi6; Liu, Tzu Ming3; Deng, Chu Xia3; Zou, Chang4; Xie, Xi5; Li, Xiaowu6; Wang, Peng Yuan1,7
2021-07-01
Source PublicationAdvanced Therapeutics
ISSN2366-3987
Volume4Issue:7
Abstract

Rare cancer cells, such as circulating tumor cells (CTCs) and cancer stem cells (CSCs), are small cell population found in cancer patients. CTCs have been recognized as tumor avatars for real-time cancer monitoring, while CSCs are the most malignant tumor cells that play a dominant role in drug resistance and metastasis. Interestingly, these two types of cells share the same surface markers, such as EpCAM, CD44, and CD133. While capturing these rare cells is available, the expansion of these cells is still challenging due to the limited cell number. These cells are susceptible to the microenvironment and lose the capability to grow in vitro, especially after an intense capturing process. A technology called patient-derived tumor organoids (PDOs) or tumoroids is a rising start in cancer modeling but the applicability is still questionable. Recently, assembloids containing multiple tumor-related cells have been developed which is one step closer to the real tumor. In this review, strategies for in vitro expansion of tumoroids are summarized implying that artificial tumor niche composed of optimized biophysical and biological cues is vital in the tumoroid generation. Tumoroids containing rare cancer cells is believed to be beneficial in the diagnosis, therapeutic regimen, and drug discovery for personalized therapy.

KeywordAssembloid Cancer Stem Cell Circulating Tumor Cell Drug Screening Microenvironment
DOI10.1002/adtp.202100017
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000650000100001
Scopus ID2-s2.0-85105886979
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorWang, Peng Yuan
Affiliation1.Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
2.University of Chinese Academy of Sciences, Beijing, 100049, China
3.Cancer Center, Faculty of Health Sciences, University of Macau, Macao, 999078, China
4.The First Affiliated Hospital of Southern University, Shenzhen People's Hospital, Shenzhen, 518020, China
5.State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou, 510275, China
6.Department of Hepatobiliary Surgery, General Hospital of Shenzhen University, Guangdong, 518055, China
7.Department of Chemistry and Biotechnology, Swinburne University of Technology, Victoria, 3122, Australia
Recommended Citation
GB/T 7714
Enkhbat, Myagmartsend,Liu, Yung Chiang,Kim, Jua,et al. Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy[J]. Advanced Therapeutics,2021,4(7).
APA Enkhbat, Myagmartsend,Liu, Yung Chiang,Kim, Jua,Xu, Yanshan,Yin, Zongyi,Liu, Tzu Ming,Deng, Chu Xia,Zou, Chang,Xie, Xi,Li, Xiaowu,&Wang, Peng Yuan.(2021).Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy.Advanced Therapeutics,4(7).
MLA Enkhbat, Myagmartsend,et al."Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen and Cancer Therapy".Advanced Therapeutics 4.7(2021).
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