Residential Collegefalse
Status已發表Published
Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor
Yang, Kuikun1,2; Yu, Guocan3; Yang, Zhiqing1,2; Yue, Ludan1,2; Zhang, Xiangjun1,2; Sun, Chen1,2; Wei, Jianwen1,2; Rao, Lang4; Chen, Xiaoyuan5,6,7; Wang, Ruibing1,2
2021-08-02
Source PublicationAngewandte Chemie - International Edition
ISSN1433-7851
Volume60Issue:32Pages:17570-17578
Abstract

The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H2O2 level in tumor tissues. Herein, we developed a supramolecular nanoparticle via a simple one-step supramolecular polymerization-induced self-assembly process using platinum (IV) complex-modified β-cyclodextrin-ferrocene conjugates as supramolecular monomers. The supramolecular nanoparticles could dissociate rapidly upon exposure to endogenous H2O2 in the tumor and release hydroxyl radicals as well as platinum (IV) prodrugs in situ, which is reduced into cisplatin to significantly promote the generation of H2O2 in the tumor tissue. Thus, the supramolecular nanomedicine overcomes the limitation of conventional chemodynamic therapy via the self-augmented cascade radical generation and drug release. In addition, dissociated supramolecular nanoparticles could be readily excreted from the body via renal clearance to effectively avoid systemic toxicity and ensure long term biocompatibility of the nanomedicine. This work may provide new insights on the design and development of novel supramolecular nanoassemblies for cascade chemo/chemodynamic therapy.

KeywordDrug Delivery Self-amplified Dissociation Self-assembly Supramolecular Polymerization Synergistic Chemo/chemodynamic Therapy
DOI10.1002/anie.202103721
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000667093100001
Scopus ID2-s2.0-85111924205
Fulltext Access
FWCI8.012935
Citation statistics
Cited Times [WOS]:63   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionMinistry of Education Frontiers Science Center for Precision Oncology, University of Macau
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding AuthorChen, Xiaoyuan; Wang, Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Taipa, Avenida da Universidade, Macao
2.MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Avenida da Universidade, Macao
3.Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, China
4.Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, China
5.Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore
6.Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
7.Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
First Author AffilicationUniversity of Macau
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Kuikun,Yu, Guocan,Yang, Zhiqing,et al. Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor[J]. Angewandte Chemie - International Edition,2021,60(32):17570-17578.
APA Yang, Kuikun,Yu, Guocan,Yang, Zhiqing,Yue, Ludan,Zhang, Xiangjun,Sun, Chen,Wei, Jianwen,Rao, Lang,Chen, Xiaoyuan,&Wang, Ruibing.(2021).Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor.Angewandte Chemie - International Edition,60(32),17570-17578.
MLA Yang, Kuikun,et al."Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor".Angewandte Chemie - International Edition 60.32(2021):17570-17578.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Kuikun]'s Articles
[Yu, Guocan]'s Articles
[Yang, Zhiqing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Kuikun]'s Articles
[Yu, Guocan]'s Articles
[Yang, Zhiqing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Kuikun]'s Articles
[Yu, Guocan]'s Articles
[Yang, Zhiqing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.