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Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy
Yue, Ludan; Yang, Kuikun; Li, Junyan; Cheng, Qian; Wang, Ruibing
2021-08-26
Source PublicationSmall
ISSN1613-6810
Volume17Issue:34
Abstract

Gas therapy has emerged as a new therapeutic strategy in combating cancer owing to its high therapeutic efficacy and biosafety. However, the clinical translation of gas therapy remains challenging due to the rapid diffusion and limited tissue penetration of therapeutic gases. Herein, a self-propelled, asymmetrical Au@MnO nanomotor for efficient delivery of therapeutic gas to deep-seated cancer tissue for enhanced efficacy of gas therapy, is reported. The Au@MnO nanoparticles (NPs) catalyze endogenous HO into O that propels NPs into deep solid tumors, where SO prodrug is released from the hollow NPs owing to the degradation of MnO shells. Fluorescein isothiocyanate (FITC) is conjugated onto the surface of Au via caspase-3 responsive peptide (DEVD) and the therapeutic process of gas therapy can be optically self-reported by the fluorescence of FITC that is turned on in the presence of overexpressed caspase-3 as an apoptosis indicator. Au@MnO nanomotors show self-reported therapeutic efficacy and high biocompatibility both in vitro and in vivo, offering important new insights to the design and development of novel nanomotors for efficient payload delivery into deep tumor tissue and in situ monitoring of the therapeutic process.

KeywordGas Therapy Nanomotors Prodrugs Responsive Release Self-reporting
DOI10.1002/smll.202102286
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000673237400001
Scopus ID2-s2.0-85109987181
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorWang, Ruibing
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yue, Ludan,Yang, Kuikun,Li, Junyan,et al. Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy[J]. Small,2021,17(34).
APA Yue, Ludan,Yang, Kuikun,Li, Junyan,Cheng, Qian,&Wang, Ruibing.(2021).Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy.Small,17(34).
MLA Yue, Ludan,et al."Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy".Small 17.34(2021).
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