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Comparative genomics provides insights into the aquatic adaptations of mammals
Yuan, Yuan1,2; Zhang, Yaolei3,4,5; Zhang, Peijun1; Liu, Chang2; Wang, Jiahao3,6; Gao, Haiyu1; Rus Hoelzel, A.7; Seim, Inge8,9; Lv, Meiqi3; Lin, Mingli1; Dong, Lijun1; Gao, Haoyang3; Yang, Zixin1; Caruso, Francesco1; Lin, Wenzhi1; Da Fonseca, Rute R.10; Wang, Ding11; Wang, Xianyan12; Rasmussen, Marianne H.13; Liu, Mingming1; Zheng, Jinsong1; Zhao, Liyuan12; Campos, Paula F.14; Kang, Hui1; Iversen, Maria13; Song, Yue3; Guo, Xinyu3; Guo, Jiao3; Qin, Yating3; Pan, Shanshan3; Xu, Qiwu3; Meng, Lingfeng3; Yunga, A.3; Liu, Shanshan3; Ming-Yuen Lee, Simon15; Liu, Xin3,4,6; Xu, Xun4; Yang, Huanming4; Fan, Guangyi3,4,6,15; Wang, Kun2; Li, Songhai1,16,17
2021-09-14
Source PublicationProceedings of the National Academy of Sciences of the United States of America
ISSN0027-8424
Volume118Issue:37
Abstract

The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (NFIA), vascular development (SEMA3E), and heat production by brown adipose tissue (UCP1) had unique changes that may contribute to marine mammal thermoregulation. We also observed many lineage-specific changes in the marine mammals, including genes associated with deep diving and navigation. Our study advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life.

KeywordAquatic Adaptation Comparative Genomics Marine Mammals
DOI10.1073/pnas.2106080118
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000697000500003
Scopus ID2-s2.0-85114743612
Fulltext Access
Citation statistics
Cited Times [WOS]:14   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorFan, Guangyi; Wang, Kun; Li, Songhai
Affiliation1.Marine Mammal and Marine Bioacoustics Laboratory, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, 572000, China
2.School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, 710072, China
3.BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, China
4.BGI-Shenzhen, Shenzhen, 518083, China
5.Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, 2800, Denmark
6.State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China
7.Department of Biosciences, Durham University, Durham, DH1 3LE, United Kingdom
8.Integrative Biology Laboratory, College of Life Sciences, Nanjing Normal University, Nanjing, 210046, China
9.School of Biology and Environmental Science, Queensland University of Technology, Brisbane, 4000, Australia
10.Center for Macroecology, Evolution, and Climate, GLOBE Institute, University of Copenhagen, Copenhagen, 1165, Denmark
11.Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China
12.Laboratory of Marine Biology and Ecology, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, 361005, China
13.Research Center in Húsavík, University of Iceland, Húsavík, 640, Iceland
14.Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, 4450-208, Portugal
15.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao
16.Tropical Marine Science Institute, National University of Singapore, Singapore, 119227, Singapore
17.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yuan, Yuan,Zhang, Yaolei,Zhang, Peijun,et al. Comparative genomics provides insights into the aquatic adaptations of mammals[J]. Proceedings of the National Academy of Sciences of the United States of America,2021,118(37).
APA Yuan, Yuan.,Zhang, Yaolei.,Zhang, Peijun.,Liu, Chang.,Wang, Jiahao.,Gao, Haiyu.,Rus Hoelzel, A..,Seim, Inge.,Lv, Meiqi.,Lin, Mingli.,Dong, Lijun.,Gao, Haoyang.,Yang, Zixin.,Caruso, Francesco.,Lin, Wenzhi.,Da Fonseca, Rute R..,Wang, Ding.,Wang, Xianyan.,Rasmussen, Marianne H..,...&Li, Songhai.(2021).Comparative genomics provides insights into the aquatic adaptations of mammals.Proceedings of the National Academy of Sciences of the United States of America,118(37).
MLA Yuan, Yuan,et al."Comparative genomics provides insights into the aquatic adaptations of mammals".Proceedings of the National Academy of Sciences of the United States of America 118.37(2021).
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