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β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats
Luo, Huijuan1; Xu, Nan1; Wu, Jiazhen1; Gan, Yuxuan3; Chen, Liping2; Guan, Fengkun1; Li, Mengyao1; Li, Yucui1; Chen, Jiannan1; Su, Ziren1,4; Liu, Yuhong1,4
2021-09-01
Source PublicationInternational Immunopharmacology
ISSN1567-5769
Volume98
Abstract

Non-alcoholic steatohepatitis (NASH), an extreme progressive subtype of metabolic associated fatty liver disease, is well characterized by hepatic steatosis, injury and inflammation. It causes irreversible hepatic damage and there are no approved interventions for it. β-PAE, a representatively pharmacological active substance isolated from Pogostemon cablin, has been indicated to alleviate hepatic steatosis and injury through modulating lipid metabolism in rats with simple steatosis. However, its protection against NASH remains unclear. Here, this study explored the potential effect of β-PAE against high-fat diet-induced NASH in rats. The results displayed that β-PAE significantly reduced the gains of body weight and epididymal adipose tissue, liver index and attenuated liver histological damages in NASH rats. It also markedly alleviated hepatic inflammation by inhibiting NLRP3 inflammasome activation. In NASH, the active NLRP3 inflammasome is caused by hepatic lipid abnormal accumulation-induced oxidative stress. Excessive oxidative stress results in hepatic histanoxia, which exacerbates lipid metabolism disorders by elevating CD36 to suppress AMPK signalling pathways. Moreover, the lipid accumulation led by lipid metabolism dysfunction intensifies oxidative stress. A vicious circle is formed among oxidative stress, histanoxia and lipid accumulation, eventually, but β-PAE effectively interrupted it. Interestingly, soluble CD36 (sCD36) was tightly associated not only with hepatic steatosis and injury but also with inflammation. Collectively, β-PAE exerted a positive effect against NASH by interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation, and sCD36 may be a promising non-invasive tool for NASH diagnosis.

KeywordHistanoxia Non-alcoholic Steatohepatitis Oxidative Stress Soluble Cd36 Β-patchoulene
DOI10.1016/j.intimp.2021.107915
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaImmunology ; Pharmacology & Pharmacy
WOS SubjectImmunology ; Pharmacology & Pharmacy
WOS IDWOS:000696813600004
Scopus ID2-s2.0-85108969889
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorSu, Ziren; Liu, Yuhong
Affiliation1.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
2.Faculty of Health Sciences, University of Macau, Macao, China
3.The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China
4.Dongguan & Guangzhou University of Chinese Medicine Cooperative Academy of Mathematical Engineering for Chinese Medicine, Dongguan, 523808, China
Recommended Citation
GB/T 7714
Luo, Huijuan,Xu, Nan,Wu, Jiazhen,et al. β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats[J]. International Immunopharmacology,2021,98.
APA Luo, Huijuan,Xu, Nan,Wu, Jiazhen,Gan, Yuxuan,Chen, Liping,Guan, Fengkun,Li, Mengyao,Li, Yucui,Chen, Jiannan,Su, Ziren,&Liu, Yuhong.(2021).β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats.International Immunopharmacology,98.
MLA Luo, Huijuan,et al."β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats".International Immunopharmacology 98(2021).
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