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Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma
Gao, Cheng1,2; Cheng, Qian2; Li, Junyan2; Chen, Jia2; Wang, Qingfu2; Wei, Jianwen2; Huang, Qiaoxian2; Lee, Simon M.Y.2; Gu, Dayong1; Wang, Ruibing2
2021-09-01
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume31Issue:37
Abstract

As many diseases are related to inflammation, the inflammatory tropism of immune cells may bring cell-hitchhikers directly to the disease tissues in a highly targeted manner. The current cell-hitchhiking strategies rely on either cellular internalization or covalent surface conjugation, which often affects the physiological function of transporting cells. Herein, a cell-friendly, host-guest chemistry mediated macrophage-liposome conjugate (M-L) is developed for extremely stable cell-hitchhiking drug delivery. M-L is prepared via simple supramolecular “hand-holding” and marriage between cucurbit[7]uril (CB[7]) and adamantane, respectively anchored on the surface of the macrophage and liposome, which demonstrates targeted accumulation in the inflamed lung and effective therapy of acute pneumonia in mice when loaded with quercetin. Upon loading toxic chemotherapeutic agents (such as doxorubicin and oxaliplatin), M-L carries the payloads to the inflammatory cancer tissue and significantly enhances the chemoimmunotherapy of melanoma in mice. Fundamentally, this CB[7]-based supramolecular M-L conjugation strategy shows negligible effects on the migratory and invasive behaviors of macrophages. In vivo pathological analysis of the inflammatory tissues in mice after treatment with M-L further suggests that macrophage and liposomes are delivered together hand in hand. This CB[7]-based, supramolecular cell-conjugation strategy potentially addresses the key challenges faced by the current cell-based delivery systems.

KeywordCell Carriers Cucurbit[7]Uril Hitchhiking Delivery Host-guest Chemistry Immunotherapy
DOI10.1002/adfm.202102440
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000666957100001
Scopus ID2-s2.0-85108781192
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Clinical Laboratory, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macao
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gao, Cheng,Cheng, Qian,Li, Junyan,et al. Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma[J]. Advanced Functional Materials,2021,31(37).
APA Gao, Cheng,Cheng, Qian,Li, Junyan,Chen, Jia,Wang, Qingfu,Wei, Jianwen,Huang, Qiaoxian,Lee, Simon M.Y.,Gu, Dayong,&Wang, Ruibing.(2021).Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma.Advanced Functional Materials,31(37).
MLA Gao, Cheng,et al."Supramolecular Macrophage-Liposome Marriage for Cell-Hitchhiking Delivery and Immunotherapy of Acute Pneumonia and Melanoma".Advanced Functional Materials 31.37(2021).
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