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Fecal multi-omics analysis reveals diverse molecular alterations of gut ecosystem in COVID-19 patients
He, Feixiang1,2; Zhang, Ting2; Xue, Kewen2; Fang, Zhaoxiong3; Jiang, Guanmin4; Huang, Siwen3; Li, Kexue4; Gu, Zhiqiang3; Shi, Honggang3; Zhang, Zhenyi3; Zhu, Huijin3; Lin, Lu3; Li, Jialin3; Xiao, Fei2,5; Shan, Hong2; Yan, Ru6; Li, Xiaofeng3; Yan, Zhixiang2
2021-10-02
Source PublicationAnalytica Chimica Acta
ISSN0003-2670
Volume1180
Abstract

Gut ecosystem has profound effects on host physiology and health. Gastrointestinal (GI) symptoms were frequently observed in patients with COVID-19. Compared with other organs, gut antiviral response can result in more complicated immune responses because of the interactions between the gut microbiota and host immunity. However, there are still large knowledge gaps in the impact of COVID-19 on gut molecular profiles and commensal microbiome, hindering our comprehensive understanding of the pathogenesis of SARS-CoV-2 and the treatment of COVID-19. We performed longitudinal stool multi-omics profiling to systemically investigate the molecular phenomics alterations of gut ecosystem in COVID-19. Gut proteomes of COVID-19 were characterized by disturbed immune, proteolysis and redox homeostasis. The expression and glycosylation of proteins involved in neutrophil degranulation and migration were suppressed, while those of proteases were upregulated. The variable domains of Ig heavy chains were downregulated and the overall glycosylation of IgA heavy chain constant regions, IgGFc-binding protein, and J chain were suppressed with glycan-specific variations. There was a reduction of beneficial gut bacteria and an enrichment of bacteria derived deleterious metabolites potentially associated with multiple types of diseases (such as ethyl glucuronide). The reduction of Ig heave chain variable domains may contribute to the increase of some Bacteroidetes species. Many bacteria ceramide lipids with a C17-sphingoid based were downregulated in COVID-19. In many cases, the gut phenome did not restore two months after symptom onset. Our study indicates widely disturbed gut molecular profiles which may play a role in the development of symptoms in COVID-19. Our findings also emphasis the need for ongoing investigation of the long-term gut molecular and microbial alterations during COVID-19 recovery process. Considering the gut ecosystem as a potential target could offer a valuable approach in managing the disease.

KeywordCovid-19 Glycoproteomics Gut Microbiome Metabolomics Metaproteomics Phenomics
DOI10.1016/j.aca.2021.338881
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000683023800005
Scopus ID2-s2.0-85111519888
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYan, Ru; Li, Xiaofeng; Yan, Zhixiang
Affiliation1.Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai, China
2.Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China
3.Department of Gastroenterology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China
4.Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China
5.Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
He, Feixiang,Zhang, Ting,Xue, Kewen,et al. Fecal multi-omics analysis reveals diverse molecular alterations of gut ecosystem in COVID-19 patients[J]. Analytica Chimica Acta,2021,1180.
APA He, Feixiang,Zhang, Ting,Xue, Kewen,Fang, Zhaoxiong,Jiang, Guanmin,Huang, Siwen,Li, Kexue,Gu, Zhiqiang,Shi, Honggang,Zhang, Zhenyi,Zhu, Huijin,Lin, Lu,Li, Jialin,Xiao, Fei,Shan, Hong,Yan, Ru,Li, Xiaofeng,&Yan, Zhixiang.(2021).Fecal multi-omics analysis reveals diverse molecular alterations of gut ecosystem in COVID-19 patients.Analytica Chimica Acta,1180.
MLA He, Feixiang,et al."Fecal multi-omics analysis reveals diverse molecular alterations of gut ecosystem in COVID-19 patients".Analytica Chimica Acta 1180(2021).
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