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A “Bridge-Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization
Mu, Ruoyu1; Zhang, Yuhan1; Yan, Lingli1; Liao, Zhencheng1; Yang, Yushun2; Su, Huanxing1; Dong, Lei2; Wang, Chunming1
2021-10-01
Source PublicationAdvanced Materials
ISSN0935-9648
Volume33Issue:42
Abstract

The globally high prevalence of peripheral artery diseases poses a pressing need for biomaterials grafts to rebuild vasculature. When implanted, they should promote endothelial cells (ECs) adhesion both profoundly and selectively—but the latter expectation remains unfulfilled. Here, this work is inspired by fungi that invade blood vessels via the “bridge” of galectins that, secreted by ECs, can simultaneously bind carbohydrates on fungal surface and integrin receptors on ECs. A glucomannan decanoate (GMDE) substrate mimicking fungal carbohydrates that highly and preferentially supports ECs adhesion while rejecting several other cell types is designed. Electrospun GMDE scaffolds efficiently sequester endogenous galectin-1—which bridges ECs to the scaffolds as it functions in fungal invasions—and promote blood perfusion in a murine limb ischemic model. Meanwhile, the application of GMDE requires no exogenous pro-angiogenic agents and causes no organ toxicity or adverse inflammation in mice, highlighting its high safety of potential translation. This glycan material, uniquely mimicking a microbial action and harnessing a secreted protein as a “bridge,” represents an effective, safe, and different strategy for ischemic vascular therapy.

KeywordAngiogenesis Blood Vessels Carbohydrates Cell Adhesion Natural Biomaterials
DOI10.1002/adma.202103490
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000692041800001
Scopus ID2-s2.0-85114100118
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorDong, Lei; Wang, Chunming
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China
2.State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Mu, Ruoyu,Zhang, Yuhan,Yan, Lingli,et al. A “Bridge-Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization[J]. Advanced Materials,2021,33(42).
APA Mu, Ruoyu,Zhang, Yuhan,Yan, Lingli,Liao, Zhencheng,Yang, Yushun,Su, Huanxing,Dong, Lei,&Wang, Chunming.(2021).A “Bridge-Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization.Advanced Materials,33(42).
MLA Mu, Ruoyu,et al."A “Bridge-Building” Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization".Advanced Materials 33.42(2021).
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