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Functionalizing Collagen with Vessel-Penetrating Two-Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia
Wu, Cheng Ham1; Kisel, Kristina S.2,3; Thangavel, Muthu Kumar2; Chen, Yi Ting1; Chang, Kai Hsin1; Tsai, Ming Rung1; Chu, Chia Yu4; Shen, Yu Fang5,6; Wu, Pei Chun7; Zhang, Zhiming7; Liu, Tzu Ming7; Jänis, Janne2; Grachova, Elena V.3; Shakirova, Julia R.3; Tunik, Sergey P.3; Koshevoy, Igor O.2; Chou, Pi Tai1
2021-10-01
Source PublicationAdvanced Science
ISSN2198-3844
Volume8Issue:20
Abstract

The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio-probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (Re) diimine carbonyl complexes is developed, which can efficaciously permeate normal vessel walls and then functionalize the extravascular collagen matrixes as in situ oxygen sensor. Without protective agents, Re-diimine complex already exhibits excellent emission yield (34%, λ = 583 nm) and large two-photon absorption cross-sections (σ = 300 GM @ 800 nm) in water (pH 7.4). After extravasation, remarkably, the collagen-bound probes further enhanced their excitation efficiency by increasing the deoxygenated lifetime from 4.0 to 7.5 µs, paving a way to visualize tumor hypoxia and tissue ischemia in vivo. The post-extravasation functionalization of extracellular matrixes demonstrates a new methodology for biomaterial-empowered phosphorescence sensing and imaging.

KeywordPhosphorescence Lifetime Imaging Microscopy Phosphorescent Oxygen Sensors Rei Diimine Carbonyl Complexes Tissue Ischemia Tumor Hypoxia Two-photon Phosphorescence
DOI10.1002/advs.202102788
URLView the original
Indexed BySSCI
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectIstry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000686381700001
Scopus ID2-s2.0-85113135189
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLiu, Tzu Ming; Tunik, Sergey P.; Koshevoy, Igor O.; Chou, Pi Tai
Affiliation1.Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan
2.Department of Chemistry, University of Eastern Finland, Joensuu, 80101, Finland
3.St.-Petersburg State University, St.-Petersburg, 7/9 Universitetskaya nab, 199034, Russian Federation
4.Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 10002, Taiwan
5.Department of Bioinformatics and Medical Engineering, Asia University, Taichung City, 41354, Taiwan
6.3D Printing Medical Research Institute, Asia University, Taichung City, 41354, Taiwan
7.Institute of Translational Medicine, Faculty of Health Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, 999078, Macao
Corresponding Author AffilicationFaculty of Health Sciences;  Faculty of Education
Recommended Citation
GB/T 7714
Wu, Cheng Ham,Kisel, Kristina S.,Thangavel, Muthu Kumar,et al. Functionalizing Collagen with Vessel-Penetrating Two-Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia[J]. Advanced Science,2021,8(20).
APA Wu, Cheng Ham,Kisel, Kristina S.,Thangavel, Muthu Kumar,Chen, Yi Ting,Chang, Kai Hsin,Tsai, Ming Rung,Chu, Chia Yu,Shen, Yu Fang,Wu, Pei Chun,Zhang, Zhiming,Liu, Tzu Ming,Jänis, Janne,Grachova, Elena V.,Shakirova, Julia R.,Tunik, Sergey P.,Koshevoy, Igor O.,&Chou, Pi Tai.(2021).Functionalizing Collagen with Vessel-Penetrating Two-Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia.Advanced Science,8(20).
MLA Wu, Cheng Ham,et al."Functionalizing Collagen with Vessel-Penetrating Two-Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia".Advanced Science 8.20(2021).
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