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Recent advances in therapeutic nucleic acids and their analytical methods
Talap, Jadera1; Zhao, Jing2; Shen, Minzhe1; Song, Zihan1; Zhou, Hui1; Kang, Yu1; Sun, Lianli1; Yu, Lushan1; Zeng, Su1,3; Cai, Sheng1,3
Source PublicationJournal of Pharmaceutical and Biomedical Analysis

Therapeutic nucleic acids are various chemically modified RNA or DNA with different functions, which mainly play roles at the gene level. Owing to its accurately targeting at pathogenic genes, nucleic acid based therapeutics have a wide range of application prospects. Recently, the improvement on chemical synthesis and delivery materials accelerated the development of therapeutic nucleic acids rapidly. Up to now, 17 nucleic acid based therapeutics approved by Food and Drug Administration (FDA) or European Medicines Agency (EMA). The development of therapeutics raised higher requirements for analytical methods, both in quality control and in clinical research. The first part of this review introduces different classes of therapeutic nucleic acids, including antisense oligonucleotide (ASO), RNA interference (RNAi) therapy, mRNA, aptamer and other classes which are under research. The second part reviews the therapeutic nucleic acids commercialized from 2019 to now. The third part discusses the analytical methods for nucleic acid based therapeutics, including liquid chromatography-based methods, capillary gel electrophoresis (CGE), hybridization enzyme-linked immunosorbent assay (ELISA) and other infrequently used methods. Finally, the advantages and shortcomings of these methods are summarized, and the future development of analysis methods are prospected.

KeywordCge Elisa Hplc Therapeutic Nucleic Acids
URLView the original
Indexed BySCIE
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS IDWOS:000706843600004
Scopus ID2-s2.0-85115637652
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZeng, Su; Cai, Sheng
Affiliation1.Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
3.Cancer Center of Zhejiang University, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Hangzhou, China
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Talap, Jadera,Zhao, Jing,Shen, Minzhe,et al. Recent advances in therapeutic nucleic acids and their analytical methods[J]. Journal of Pharmaceutical and Biomedical Analysis,2021,206.
APA Talap, Jadera,Zhao, Jing,Shen, Minzhe,Song, Zihan,Zhou, Hui,Kang, Yu,Sun, Lianli,Yu, Lushan,Zeng, Su,&Cai, Sheng.(2021).Recent advances in therapeutic nucleic acids and their analytical methods.Journal of Pharmaceutical and Biomedical Analysis,206.
MLA Talap, Jadera,et al."Recent advances in therapeutic nucleic acids and their analytical methods".Journal of Pharmaceutical and Biomedical Analysis 206(2021).
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